1380432-36-9Relevant academic research and scientific papers
First total synthesis of (+)-heteroplexisolide e
Kutsumura, Noriki,Kiriseko, Akito,Saito, Takao
, p. 3274 - 3276 (2012)
In this study, we achieved the first total synthesis of (+)-heteroplexisolide E. The synthetic highlights of our approach include a one-pot regioselective methylation method and the transformation of a β-methallyl alcohol moiety to a prenyl group using palladium-catalyzed hydrogenolysis.
One-pot method for regioselective bromination and sequential carbon-carbon bond-forming reactions of allylic alcohol derivatives
Kutsumura, Noriki,Matsubara, Yusuke,Niwa, Kentaro,Ito, Ai,Saito, Takao
, p. 3337 - 3346 (2013/06/27)
An efficient one-pot method for the regioselective bromination of allylic alcohol derivatives (two-step reaction sequence) followed by Sonogashira, Negishi, or Suzuki-Miyaura coupling reactions in the same reaction vessel (three-step reaction sequence) ha
Total synthesis of (+)-heteroplexisolide E
Kutsumura, Noriki,Kiriseko, Akito,Saito, Takao
, p. 1367 - 1378 (2013/08/23)
Total synthesis of (+)-heteroplexisolide E has been demonstrated. The synthetic approach exploits the one-pot regioselective Negishi coupling (methylation) and transformation of a β-methallyl alcohol moiety to a branched prenyl group via palladium-catalyzed hydrogenolysis. For the introduction of the 4-oxo-pentylidene side chain, two independent methods were devised: olefin cross metathesis (CM) (route A) and aldol condensation (route B).
