1449005-70-2Relevant academic research and scientific papers
Total synthesis of (+)-heteroplexisolide E
Kutsumura, Noriki,Kiriseko, Akito,Saito, Takao
, p. 1367 - 1378 (2013/08/23)
Total synthesis of (+)-heteroplexisolide E has been demonstrated. The synthetic approach exploits the one-pot regioselective Negishi coupling (methylation) and transformation of a β-methallyl alcohol moiety to a branched prenyl group via palladium-catalyzed hydrogenolysis. For the introduction of the 4-oxo-pentylidene side chain, two independent methods were devised: olefin cross metathesis (CM) (route A) and aldol condensation (route B).
