1380445-22-6

Basic information

• Product Name: (4-bromo-3-nitrophenyl)carbamic acid tert-butyl ester
• Synonyms: (4-bromo-3-nitrophenyl)carbamic acid tert-butyl ester
• CAS NO: 1380445-22-6
• Molecular Weight: 317.139
• Mol File: 1380445-22-6.mol

Chemical Properties

• CAS DataBase Reference: (4-bromo-3-nitrophenyl)carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (4-bromo-3-nitrophenyl)carbamic acid tert-butyl ester(1380445-22-6)
• EPA Substance Registry System: (4-bromo-3-nitrophenyl)carbamic acid tert-butyl ester(1380445-22-6)

Safety Data

• Hazardous Substances Data: 1380445-22-6(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(4-bromo-3-nitrophenyl)carbamic acid tert-butyl ester is utilized as a reagent in organic synthesis for the preparation of pharmaceutical intermediates and agrochemicals. Its unique structure and functional groups make it a valuable component in the development of various chemical compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (4-bromo-3-nitrophenyl)carbamic acid tert-butyl ester is used as a precursor for the synthesis of active pharmaceutical ingredients. Its electron-donating substituents and reactivity contribute to the creation of new drug candidates with potential therapeutic applications.
Used in Agrochemical Industry:
(4-bromo-3-nitrophenyl)carbamic acid tert-butyl ester is also employed in the agrochemical industry for the synthesis of compounds with pesticidal properties. Its chemical structure allows for the development of new agrochemicals aimed at enhancing crop protection and yield.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 53324-38-2 4-bromo-3-nitroaniline 

Downstream Products

• 819850-13-0 (1H-Indol-4-yl) carbamic acid tert-butyl ester 
• 885270-70-2 tert-butyl (3-amino-4-bromophenyl)carbamate 

Relevant articles and documents

MOLECULES HAVING CERTAIN PESTICIDAL UTILITIES, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES RELATED THERETO

This disclosure relates to compounds having pesticidal utility against pests in phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce such compounds and intermediates used in such processes, compositions containing such compounds, and processes of using such compounds against such pests. These compounds/molecules may be used, for example, as nematicides, acaricides, insecticides, miticides, and/or molluscicides. This document discloses compounds having the following formula (Formula One and/or Formula One-A).

INHIBITOR OF BTK AND MUTANTS THEREOF

The disclosure includes compounds of Formula (I) (1) wherein Q0, Q1, Q2, Q3, Q4, Z, W, i, j, m, n, Warhead, R0, R1, R3, R4, R5, R6, and R7, are defined herein. Also disclosed is a method for treating a neoplastic disease, autoimmune disease, and inflammatory disorder with these compounds.

Small molecule compound

The invention provides a small molecular compound, The small molecular compound is characterized by having a structure as shown in the following molecular general formula, wherein X1 and X2 are selected from carbon or nitrogen, G1 is a carbon ring or a heterocyclic ring with aromaticity, any one or more hydrogen atoms on the G1 ring are substituted by R1, wherein R1 is selected from nitrogen-containing groups. The small molecule compound can be used as an efficient and specific JAK kinase inhibitor, especially a Tyk2 inhibitor, and/or a JAK1 inhibitor, and/or a JAK1/Tyk2 dual inhibitor, or a Tyk2/JAK1 dual inhibitor or a Tyk2/Jak2 dual inhibitor.

FACTOR XIa INHIBITORS

The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma Kallikrein.

MACROCYCLIC SPIROCARBAMATE DERIVATIVES AS FACTOR XIA INHIBITORS, PHARMACEUTICALLY ACCEPTABLE COMPOSITIONS AND THEIR USE

The present invention provides a compound of Formula (I) and stereoisomers thereof, and pharmaceutically acceptable salts of said compounds and said stereoisomers, and pharmaceutical compositions thereof, and methods for using said compounds and compositi

Heterocyclic derivate tyrosine kinase inhibitor

The invention belongs to the technical field of medicine and particularly relates to a heterocyclic derivate tyrosine kinase inhibitor shown in the formula (I), a pharmaceutically acceptable salt and ester thereof and stereoisomers thereof, wherein Y, W, Q m, L, R1, R2, R3, R4, R5, R6, R7, R7', R8 and R8' are defined in the specification. The invention further relates to a preparation method of the compounds and a pharmaceutical preparation and pharmaceutical compositions containing the compounds, and application of the compounds as the tyrosine kinase inhibitor for preparing medicine for preventing and/or treating cancer diseases caused by EGFR mutation and drug resistance diseases caused by EGFR T790M mutation.

Synthesis of amino-substituted indoles using the Bartoli reaction

We report herein the concise preparation of a range of functionalised aminoindoles via a new application of the Bartoli reaction. Scope and limitations of the methodology have been extensively studied to reveal the importance of protecting groups and subs