1380489-89-3Relevant academic research and scientific papers
Synthesis and immunological screening of β-linked mono- and divalent mannosides
Mukherjee, Chinmoy,Ranta, Kaarina,Savolainen, Johannes,Leino, Reko
experimental part, p. 2957 - 2968 (2012/07/14)
Three different β-linked divalent mannosides, along with their corresponding monovalent counterparts, have been designed and chemically synthesized by coupling the corresponding propargyl (propargyl alcohol in the case of the monovalent compounds) and 2-azidoethyl glycosides by using an efficient click chemistry protocol. Crich's β-mannosylation methodology was applied to the construction of the β-mannosidic linkages. All the glycosylation reactions gave moderate-to-good yields with high selectivities. A competitive inhibition enzyme-linked immunosorbent assay (ELISA) was performed to determine the inhibition, by the synthesized mannosides, of specific human IgG binding to low-molecular-weight Candida albicans mannan; moderate inhibition capacity was observed for some of the compounds. Copyright
