1380495-39-5

Upstream product

• 7768-28-7 2-(2-hydroxyphenyl)ethanol 
• 6482-24-2 2-Bromoethyl methyl ether 

Downstream Products

• 1380495-66-8 N-[(1R)-1-(4-fluorophenyl)-2-methylpropyl]-2-(1-{2-[2-(2-methoxyethoxy)phenyl]ethyl}piperidin-4-yl)acetamide hydrochloride 
• 1380495-65-7 2-(1-{2-[4-fluoro-2-(2-methoxyethoxy)phenyl]ethyl}-piperidin-4-yl)-N-[(1R)-1-(4-fluorophenyl)-2-methylpropyl]-acetamide 
• 1380495-40-8 2-[2-(2-methoxyethoxy)phenyl]ethyl 4-methylbenzenesulfonate 

Relevant academic research and scientific papers

AMINOPEPTIDASE A INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME

The present invention relates to a novel compound, to a composition comprising the same, to methods for preparing the compound, and the use of this compound in therapy. In particular, the present invention relates to compound that is useful in the treatment and prevention of primary and secondary arterial hypertension, ictus, myocardial ischaemia, cardiac and renal insufficiency, myocardial infarction, peripheral vascular disease, diabetic proteinuria, Syndrome X and glaucoma.

Synthesis and pharmacological evaluation of 2-(1-alkylpiperidin-4-yl)-N- [(1R)-1-(4-fluorophenyl)-2-methylpropyl]acetamide derivatives as novel antihypertensive agents

We synthesized and evaluated the inhibitory activity of a series of 2-(1-alkylpiperidin-4-yl)-N-[(1R)-1-(4-fluorophenyl)-2-methylpropyl]acetamide derivatives against T-type Ca2+ channels. Structure-activity relationship studies revealed that th