1380501-06-3Relevant articles and documents
Efficient total synthesis of manzacidin B
Shinada, Tetsuro,Oe, Kentaro,Ohfune, Yasufumi
, p. 3250 - 3253 (2012)
The highly diastereoselective synthesis of the marine natural product, (-)-manzacidin B, is described. A novel copper-catalyzed aldol reaction of the α-methylserine-derived aldehyde with an isocyanoacetate possessing (1R)-camphorsultam as the chiral auxiliary proceeded in a highly diastereoselective manner to give the (4R,5R,6R)-adduct, which was converted into manzacidin B in a few steps.