1380503-19-4Relevant academic research and scientific papers
Rh-catalyzed oxidative C2-alkenylation of indoles with alkynes: Unexpected cleavage of directing group
Sharma, Satyasheel,Han, Sangil,Shin, Youngmi,Mishra, Neeraj Kumar,Oh, Hyunji,Park, Jihye,Kwak, Jong Hwan,Shin, Beom Soo,Jung, Young Hoon,Kim, In Su
, p. 3104 - 3107 (2014/05/20)
A rhodium-catalyzed oxidative C2-alkenylation of indoles containing a N-(p-tolyl)carboxamide group with substituted alkynes via C-C bond formation and subsequent C-N bond cleavage has been described. This protocol represents direct access to C-2-alkenylated free (NH)-indoles, which are important building blocks in the synthesis of natural and pharmacological compounds.
Mild and efficient C2-alkenylation of indoles with alkynes catalyzed by a cobalt complex
Ding, Zhenhua,Yoshikai, Naohiko
, p. 4698 - 4701 (2012/07/03)
Direct alkenylation of the C2-position of indoles bearing an easily removable N-pyrimidyl group with alkynes has been achieved by using a cobalt catalyst complexed with a phosphine-pyridine bidentate ligand. This reaction has wide substrate scope and is highly efficient and stereoselective at room temperature. The alkenylated indoles serve as useful platforms for further synthetic transformations (some products of these transformations are shown in the scheme). Copyright
