1380572-67-7

Basic information

• Product Name: ((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl chloride
• Synonyms: ((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl chloride
• CAS NO: 1380572-67-7
• Molecular Weight: 434.961
• Mol File: 1380572-67-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: ((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl chloride(1380572-67-7)
• EPA Substance Registry System: ((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl chloride(1380572-67-7)

Safety Data

• Hazardous Substances Data: 1380572-67-7(Hazardous Substances Data)

Upstream product

• 4136-95-2 2,4,6-trichlorobenzoyl chloride 
• 33719-74-3 3,5-dichloroanisole 
• 1380572-64-4 (2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methanone 
• 1380572-66-6 (((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl) methyl sulfide 

Downstream Products

• 1380572-83-7 (2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methyl 2,2,2-trifluoroacetate 
• 1380572-69-9 1-[5-(tert-butyldimethylsilanyloxymethyl)-3,4-dihydroxytetrahydrofuran-2-yl]-3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1H-pyrimidine-2,4-dione 
• 1380572-70-2 3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1-(3,4-dihydroxy-5-(trityloxymethyl)-tetrahydrofuran-2-yl)-1H-pyrimidine-2,4-dione 
• 1380572-72-4 C₃₆H₄₃Cl₅N₂O₈Si 
• 1380572-73-5 C₄₉H₄₃Cl₅N₂O₈ 
• 1380572-74-6 C₃₀H₂₉Cl₅N₂O₈ 
• 1380572-77-9 O,O'-((2R,3R,4R,5R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-(3-(((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl) S,S'-dimethyl dicarbonodithioate 
• 1380572-78-0 1-[5-(tert-butyldimethylsilanyloxymethyl)-2,5-dihydrofuran-2-yl]-3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1H-pyrimidine-2,4-dione 
• 1380572-68-8 3-[(2,6-dichloro-4-methoxy-phenyl)-(2,4,6-trichloro-phenyl)-methoxymethyl]-1-(3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione 

Relevant articles and documents

IMPROVED SYNTHESIS OF CAPURAMYCIN AND ITS ANALOGUES

Provided herein are compounds of Formula I, Formula II, and Formula X, which are useful for the treatment of infectious diseases. Also provided herein are processes for preparing 1-[5-0-[4,6-Dideoxy-6-oxo-6-[[[(3S)-hexahydro-2-oxo-1H-azepine]-3-y1]amino]-Pβ-L-erythro-4- hexenopyranosyl]-3-0-methyl 6-deoxy-6-amino-α-L-talofuranuronosyl]-1,2,3,4-tetrahydro-2,4- dioxopyrimidine (capuramycin), analogues thereof, and intermediates useful therefore. Also provided herein are III, IIIa, and IX, which are useful in the process for preparing capuramycin and/or a certain compound of Formula I.

A new protecting group and linker for uridine ureido nitrogen

(2,6-Dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl) methoxymethyl chloride [1, monomethoxydiph-enylmethoxylmethyl chloroide (MDPM-Cl)] shows a significant relative stability and 1 reacts with uridine ureido nitrogen in the presence of DBU to form the corresponding protected uridine 8 in 95% yield. The MDPM-protected uridines are stable to a wide variety of conditions utilized for the synthesis of analogs of capuramycin and muraymycins. Significantly, the MDPM protecting group can conveniently be deprotected by using 30% TFA in CH 2Cl2. In addition, polymer-bound MDPM-Cl 23 is useful for immobilization of uridine derivatives.