1380574-63-9Relevant academic research and scientific papers
A facile one-pot synthesis of substituted thieno[2,3- b ]pyridines from enaminones
Gao, Baochang,Dong, Dewen,Zhang, Jie,Ding, Changjiang,Dong, Chunming,Liang, Yongjiu,Zhang, Rui
experimental part, p. 201 - 206 (2012/03/26)
A facile and efficient one-pot synthesis of substituted thieno[2,3-b]pyridines has been developed. Treatment of enamin-ones, such as 2-acetyl-3-(dimethylamino)propenamides and -propenoates, with 2-cyanothioacetamide in the presence of potassium carbonate in N,N-dimethylformamide at 80 C followed by addition of methylene-active bromides at room temperature provided, via intramolecular cyclization, 2,3,5,6-tetrasubstituted thieno[2,3-b]pyridines in yields of 78-90%. This protocol, which combines construction and modification of the thieno[2,3-b]pyridine ring, increases the structural diversity of the final products from readily available materials. Georg Thieme Verlag Stuttgart · New York.
