13807-14-2

Upstream product

• 420-04-2 CYANAMID 
• 103-72-0 phenyl isothiocyanate 
• 78-95-5 chloroacetone 
• 3043-28-5 3-bromopentane-2,4-dione 
• 60093-30-3 4-phenyl-3-thio-allophanonitrile; sodium salt 
• 15989-47-6 1-phenyl-3-guanylthiourea 
• 598-31-2 1-bromoacetone 

Relevant academic research and scientific papers

NBS-mediated sequential one-pot synthesis of multifunctionalized thiazoles and thiophenes from 1,3-dicarbonyl compounds and mercaptonitrile salts

A NBS-mediated sequential one-pot synthesis of multifunctionalized thiazoles and thiophenes from 1,3-dicarbonyl compounds and mercaptonitrile salts has been developed under mild conditions. This transformation involves sequential bromination/SN

Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases

Cyclin-dependent kinases (CDKs) are serine/threonine protein kinases that act as key regulatory elements in cell cycle progression. We describe the development of highly potent diaminothiazole inhibitors of CDK2 (IC50 = 0.0009-0.0015 μM) from a

Inhibitors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma

The use of inhibitors of GSK-3 useful for treating glaucoma is disclosed.

Use of 2,4-diaminothiazole derivatives

2,4-Diaminothiazole derivatives which inhibit GSK-3 (glycogen synthase kinase-3) and which are useful for the treatment and/or prevention disorders and diseases wherein an inhibition of GSK-3 is beneficial, especially especially Alzheimer's disease, bipolar disorder, IGT (impaired glucose tolerance), Type 1 diabetes, Type 2 diabetes and obesity.

Studies on the Synthesis of 5-Acyl-2,4-diaminothiazoles from Amidinothioureas

1-Alkyl or aryl-3-amidinothioureas with or without substituents on the amidino moiety react with α-haloketones to yield 5-acyl-2,4-diaminothiazoles.