138078-57-6

Basic information

• Product Name: (+)-(2R,5S,7S)-1-aza-3-oxa-2-phenyl-7-allylbicyclo<3.3.0>octan-8-one
• Synonyms: (+)-(2R,5S,7S)-1-aza-3-oxa-2-phenyl-7-allylbicyclo<3.3.0>octan-8-one
• CAS NO: 138078-57-6
• Molecular Weight: 243.305
• Mol File: 138078-57-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (+)-(2R,5S,7S)-1-aza-3-oxa-2-phenyl-7-allylbicyclo<3.3.0>octan-8-one(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-(2R,5S,7S)-1-aza-3-oxa-2-phenyl-7-allylbicyclo<3.3.0>octan-8-one(138078-57-6)
• EPA Substance Registry System: (+)-(2R,5S,7S)-1-aza-3-oxa-2-phenyl-7-allylbicyclo<3.3.0>octan-8-one(138078-57-6)

Safety Data

• Hazardous Substances Data: 138078-57-6(Hazardous Substances Data)

Upstream product

• 556-56-9 allyl iodid 
• 103201-79-2 (3R,7aS)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one 
• 106-95-6 allyl bromide 

Relevant articles and documents

Stereoselective alkylations of a bicyclic lactam derived from pyroglutamic acid

Improvements in the stereoselective alkylation of a bicyclic lactam derived from pyroglutamic acid are described. This methodology is used to synthesize a conformationally constrained homo-glutamic acid analog.

Functionalised pyrrolidinones derived from (S)-pyroglutamic acid

The generation of the lactam enolate derived from bicyclic lactams 2a-c, prepared from (S)-pyroglutamic acid 1a, and subsequent reaction with a range of electrophiles, is reported. Exo-diastereoselectivity is generally favoured. The deprotection of some of these adducts to give functionalised hydroxymethylpyrrolidinones is readily achieved by simple hemiaminal ether cleavage under acidic conditions.