1380783-59-4

Basic information

• Product Name: 4-bromo-methyl-3-phenylfuroxan
• Synonyms: 4-bromo-methyl-3-phenylfuroxan
• CAS NO: 1380783-59-4
• Molecular Weight: 255.071
• Mol File: 1380783-59-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-bromo-methyl-3-phenylfuroxan(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-methyl-3-phenylfuroxan(1380783-59-4)
• EPA Substance Registry System: 4-bromo-methyl-3-phenylfuroxan(1380783-59-4)

Safety Data

• Hazardous Substances Data: 1380783-59-4(Hazardous Substances Data)

Upstream product

• 135733-31-2 4-(hydroxymethyl)-3-phenylfuroxan 

Downstream Products

• 1380783-74-3 C₁₅H₁₂N₂O₃ 
• 1380783-62-9 4-(3-phenylfuroxan-4-yl-methoxy)benzenesulfonamide 
• 1380783-68-5 C₂₀H₂₂N₄O₆S 

Relevant articles and documents

Furazan and furoxan sulfonamides are strong α-carbonic anhydrase inhibitors and potential antiglaucoma agents

A series of furazan and furoxan sulfonamides were prepared and studied for their ability to inhibit human carbonic anhydrase (CA, EC 4.2.1.1) isoforms hCA I, hCA II, hCA IX, and hCA XII. The simple methyl substituted products 3-5 were potent inhibitors. Differing structural modifications of these leads had differing effects on potency and selectivity. In particular, products in which the sulfonamide group is separated from the hetero ring by a phenylene bridge retained high potency only on the hCA XII isoform. The sulfonamides 3-5 exerted intraocular pressure (IOP) lowering effects in vivo in hypertensive rabbits more efficiently than dorzolamide. Some other products (39-42), although less effective in vitro hCA II/XII inhibitors, also effectively lowered IOP in two different animal models of glaucoma.