1380783-68-5Relevant articles and documents
Synthesis and preliminary biological profile of new NO-donor tolbutamide analogues
Tamboli, Yasinalli,Lazzarato, Loretta,Marini, Elisabetta,Guglielmo, Stefano,Novelli, Michela,Beffy, Pascale,Masiello, Pellegrino,Fruttero, Roberta,Gasco, Alberto
, p. 3810 - 3815 (2012/07/27)
We describe a new class of NO-donor hypoglycemic products obtained by joining tolbutamide, a typical hypoglycemic sulfonylurea, with a NO-donor moiety through a hard link. As NO-donors we chose either furoxan (1,2,5-oxadiazole 2-oxide) derivatives or the classical nitrooxy function. A preliminary biological characterization of these compounds, including stimulation of insulin release from cultured rat pancreatic β-cells and in vitro vasodilator and anti-aggregatory activities, is reported.