138079-59-1

Usage

Uses

Used in Pharmaceutical Synthesis:
(R)-(3-hydroxy-2,3-dimethylbutyl)triphenylphosphonium iodide is used as a phase transfer catalyst for the synthesis of pharmaceuticals, enabling the efficient transfer of hydroxy-functionalized alkyl groups between phases, which is crucial for the production of various medicinal compounds.
Used in Agrochemical Synthesis:
In the agrochemical industry, (R)-(3-hydroxy-2,3-dimethylbutyl)triphenylphosphonium iodide serves as a phase transfer catalyst, aiding in the synthesis of agrochemicals by promoting the transfer of specific alkyl groups, thereby enhancing the efficiency of the production process.
Used in Natural Product Synthesis:
(R)-(3-hydroxy-2,3-dimethylbutyl)triphenylphosphonium iodide is utilized as a reagent in the synthesis of natural products, where its ability to act as a phase transfer catalyst is invaluable for the successful synthesis of complex natural compounds.
Used in Organic Transformations:
This phosphonium salt is also used as a reagent in various organic transformations, where its unique properties contribute to the advancement of chemical reactions, leading to the formation of desired products in organic chemistry research and development.

Upstream product

• 23985-53-7 (R)-3-hydroxy-2,3-dimethylbutansaeure 
• 131249-23-5 R-4-Iodo-2,3-dimethyl-2-butanol 
• 603-35-0 triphenylphosphine 
• 73295-12-2 (S)-2,3-dimethyl-1,3-butanediol 
• 93748-48-2 (S)-3-hydroxy-2,3-dimethylbutyl 4-methylbenzenesulfonate 

Downstream Products

• 68702-86-3 Benzoic acid (1R,4S,7aR)-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-yl ester 
• 143317-47-9 (E)-(S)-2,3-Dimethyl-5-phenyl-pent-4-en-2-ol 
• 143317-49-1 R-(+)-4,5,5-Trimethyl-2,2,2-triphenyl-1,2-oxaphospholane 
• 138079-58-0 (R)-2,3-Dimethyl-4-(triphenyl-λ⁵-phosphanylidene)-butan-2-ol 

Relevant academic research and scientific papers

A short and efficient synthesis of DE-A,B(22E,24S)-8β-(benzoyloxy)-25-hydroxyergost-22-ene a valuable intermediate in the total synthesis of 25-hydroxylated vitamin D2-metabolites

The titel compound was synthesised in 8 steps starting from vitamin D2. The side-chain was constructed using a chiral, stereoselective Wittig-reagent.

Preparation method of paricalcitol intermediate

The invention relates to a preparation method of a paricalcitol intermediate, in particular to a preparation method for an intermediate (as shown in a formula (I)) for synthesizing paricalcitol (II). According to the method, a chiral intermediate as shown in a formula (V) through anti-and syn-aldol reaction of a chiral compound as shown in a formula (IV) and acetone, and the intermediate (as shown in a formula (I)) for synthesizing the paricalcitol is obtained through reduction, halogenations and reaction with triphenyl phosphine. The method has the advantages of mild reaction condition, simplicity and convenience in operation, high optical purity, low synthesis cost and the like, and is suitable for large-scale production. (The formulas are as shown in the description.).

METHODS FOR PRODUCING PARICALCITOL

The present invention is directed to novel processes for the preparation of paricalcitol to novel intermediates used in these processes, and to processes for preparation of the novel intermediates.

Phosphorus ylide chemistry investigated for dihydrotachysterol2 metabolite side-chain synthesis: The Wittig approach

The behaviour of the γ-oxido ylide of R-(3-hydroxy-2,3-dimethylbutyl)triphenylphosphonium iodide 4, to be used in the 25-hydroxylated DHT2 side-chain synthesis, was studied. The synthesis of the chiral phosponium salt 4 was done in an overall y