13808-65-6

Basic information

• Product Name: 4-BROMO-3-PHENYL-1H-PYRAZOLE
• Synonyms: 4-BROMO-3-PHENYL-1H-PYRAZOLE;4-Bromo-3-phenyl-1(2)H-pyrazole;4-Bromo-3-phenylpyrazole;3-phenyl-4-bromo-1H-pyrazole;4-bromo-5-phenyl-1H-pyrazole
• CAS NO: 13808-65-6
• Molecular Formula: C₉H₇BrN₂
• Molecular Weight: 223.06928
• Mol File: 13808-65-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 116-117 °C(Solv: ethanol (64-17-5))
• Boiling Point: 365.8±22.0 °C(Predicted)
• Appearance: /
• Density: 1.565±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 12.23±0.50(Predicted)
• CAS DataBase Reference: 4-BROMO-3-PHENYL-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-3-PHENYL-1H-PYRAZOLE(13808-65-6)
• EPA Substance Registry System: 4-BROMO-3-PHENYL-1H-PYRAZOLE(13808-65-6)

Safety Data

• Hazardous Substances Data: 13808-65-6(Hazardous Substances Data)

Usage

General Description

4-Bromo-3-phenyl-1H-pyrazole is a chemical compound with the molecular formula C9H7BrN2. It is a pyrazole derivative with a bromine substituent at position 4 and a phenyl group at position 3. 4-BROMO-3-PHENYL-1H-PYRAZOLE is commonly used in the synthesis of various pharmaceuticals and agrochemicals due to its versatile reactivity and potential pharmacological activities. It is also utilized as a building block in organic synthesis and medicinal chemistry research. Additionally, 4-Bromo-3-phenyl-1H-pyrazole has been investigated for its potential anticonvulsant and analgesic properties, making it a subject of interest in drug development and research.

Upstream product

• 2458-26-6 3-phenylpyrazole 
• 98-80-6 phenylboronic acid 
• 26033-20-5 3-Phenyl-1H-pyrazole-4-carboxaldehyde 

Downstream Products

• 105994-77-2 4-bromo-1-methyl-5-phenyl-1H-pyrazole 
• 105994-55-6 4-bromo-1-methyl-3-phenyl-1H-pyrazole 
• 1002334-06-6 1-methyl-3-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 
• 1238702-09-4 4-bromo-3-phenyl-1-trityl-1H-pyrazole 
• 1092565-13-3 4-bromo-3-phenyl-1-(4-toluenesulfonyl)-1H-pyrazole 
• 59843-34-4 2-(4-bromo-3-phenyl-pyrazol-1-yl)-N,N-dimethyl-propionamide 
• 59843-35-5 2-(4-bromo-5-phenyl-pyrazol-1-yl)-N,N-dimethyl-propionamide 
• 1231309-91-3 tert-butyl 2-(((1s,4s)-4-((4-bromo-5-phenyl-1H-pyrazol-1-yl)methyl)cyclohexyl)methoxy)acetate 
• 1231309-89-9 tert-butyl 2-(((1s,4s)-4-((4-bromo-3-phenyl-1H-pyrazol-1-yl)methyl)cyclohexyl)methoxy)acetate 
• 1231302-87-6 2-(((1s,4s)-4-((4-(4-chlorophenyl)-3-phenyl-1H-pyrazol-1-yl)methyl)cyclohexyl)methoxy)acetic acid 
• 1092565-12-2 2-(3-phenyl-1H-pyrazol-4-yl)-8-(4-pyridinyl)-1,5-naphthyridine 

Relevant articles and documents

The interplay of hydrogen bonds and halogen bonds in the structure of NH-pyrazoles bearing C-aryl and C-halogen substituents

The behavior in solution and in the solid state of 3(5)-phenyl-1H-pyrazole (7), 3(5)-phenyl-4-chloro-1H-pyrazole (6), 3(5)-phenyl-4-bromo-1H-pyrazole (1), and 3(5)-p-chlorophenyl-4-bromo-1H-pyrazole (8) is discussed in relation to their 3-phenyl (a)/5-phe

Photocatalytic Oxidative Bromination of Electron-Rich Arenes and Heteroarenes by Anthraquinone

The estimated excited oxidation potential of sodium anthraquinone-2-sulfonate (SAS) increases from 1.8 V to about 2.3 V vs SCE by protonation with Br?nsted acids. This increased photooxidation power of protonated anthraquinone was used for the regio-selective oxidative bromination of electron rich (hetero)arenes and drugs in good yield. The mild reaction conditions are compatible with many functional groups, such as double and triple bonds, ketones, amides and amines, hydroxyl groups, carboxylic acids and carbamates. Mechanistic investigations indicate the photooxidation of the arene followed by nucleophilic bromide addition as the likely pathway. (Figure presented.).

Discovery of Potent and Selective RSK Inhibitors as Biological Probes

While the p90 ribosomal S6 kinase (RSK) family has been implicated in multiple tumor cell functions, the full understanding of this kinase family has been restricted by the lack of highly selective inhibitors. A bis-phenol pyrazole was identified from hig