105994-77-2

Basic information

• Product Name: 4-BROMO-1-METHYL-5-PHENYL-1H-PYRAZOLE, 97
• Synonyms: 4-BROMO-1-METHYL-5-PHENYL-1H-PYRAZOLE, 97
• CAS NO: 105994-77-2
• Molecular Formula: C₁₀H₉BrN₂
• Molecular Weight: 237.099
• Mol File: 105994-77-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 62℃
• Boiling Point: 155-156 °C(Press: 12 Torr)
• Appearance: /
• Density: 1.4199 g/cm3(Temp: 56.6 °C)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 0.04±0.10(Predicted)
• CAS DataBase Reference: 4-BROMO-1-METHYL-5-PHENYL-1H-PYRAZOLE, 97(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-1-METHYL-5-PHENYL-1H-PYRAZOLE, 97(105994-77-2)
• EPA Substance Registry System: 4-BROMO-1-METHYL-5-PHENYL-1H-PYRAZOLE, 97(105994-77-2)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• Hazardous Substances Data: 105994-77-2(Hazardous Substances Data)

Usage

General Description

4-Bromo-1-methyl-5-phenyl-1H-pyrazole, 97 is a chemical compound with the molecular formula C10H9BrN2. It is a pyrazole derivative that contains a bromine atom, a methyl group, and a phenyl group. This chemical is commonly used as a building block in organic synthesis and is also being investigated for its potential biological and pharmacological activities. It is available in a purity of 97% and is used in various research and industrial applications.

Upstream product

• 3463-27-2 1-methyl-5-phenyl-1H-pyrazole 
• 13808-65-6 4-bromo-3(5)-phenyl-1H-pyrazole 
• 77-78-1 dimethyl sulfate 
• 3463-26-1 1-methyl-3-phenyl-1H-pyrazole 
• 15803-02-8 4-bromo-1-methyl-1H-pyrazole 
• 108-86-1 bromobenzene 
• 2458-26-6 3-phenylpyrazole 
• 57623-20-8 3-benzoyloxy-1-phenyl-propenone 
• 3506-51-2 Benzoyl acetaldehyde 
• 5443-49-2 α-bromocinnamaldehyde 
• 35431-71-1 3-methyl-4-phenylsydnone 
• 52816-35-0 dimethyl 1-methyl-5-phenylpyrazole-3,4-dicarboxylate 
• 105994-74-9 1-methyl-5-phenylpyrazole-3,4-dicarboxylic acid 
• 74641-60-4 2-methylamino-2-phenylacetic acid 

Downstream Products

• 141334-91-0 4,5-diphenyl-1-methylpyrazole 
• 105994-78-3 1-Methyl-5-phenyl-1H-pyrazole-4-carbonyl chloride 
• 80326-71-2 methyl 1-methyl-5-phenyl-1H-pyrazole-4-carboxylate 
• 105994-75-0 1-methyl-5-phenyl-1H-pyrazole-4-carboxylic acid 

Relevant articles and documents

Direct (Hetero)arylation of Heteroarenes Catalyzed by Unsymmetrical Pd-PEPPSI-NHC Complexes under Mild Conditions

With the aim of developing a facile and efficient method to access structurally intriguing and valuable functionalized (hetero)aryls, two unsymmetrical Pd-PEPPSI-type NHC complexes (PEPPSI, pyridine-enhanced precatalyst preparation, stabilization, and initiation; NHC, N-heterocyclic carbene) were designed and synthesized to catalyze the direct arylation of heteroarenes with (hetero)aryl bromides. The results demonstrated that the utilization of this "unsymmetrical"strategy led to much higher efficiency in comparison to the commonly used C2-symmetric Pd-PEPPSI-type NHC complexes. Furthermore, a broad range of heteroaromatics and (hetero)aryl bromide partners with a wide variety of functional groups were all amenable to the developed protocol even at as low as 0.05 mol % catalyst loading and under aerobic conditions. More importantly, along with our study, we also found that the present protocol could provide expedient access to the gram-scale synthesis of the muscle relaxant drug dantrolene and conjugated mesopolymers.

Benzoyl phenyl 1-methylpyrazoles. Synthesis, characterization, and spectra

The synthesis and unequivocal characterization of all six isomers of benzoyl phenyl 1-methylpyrazole (2) are described.The isomer of 2 isolated as one of the products of the reaction of 1,1-dimethyl-1-phenacylhydrazinium bromide (1) with base was shown to be only previously reported isomer, 5-benzoyl-3-phenyl-1-methylpyrazole (2b).