105994-77-2

Usage

Uses

Used in Organic Synthesis:
4-BROMO-1-METHYL-5-PHENYL-1H-PYRAZOLE, 97 is used as a building block in organic synthesis for the creation of various complex organic molecules. Its unique structure allows for versatile chemical reactions, making it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-BROMO-1-METHYL-5-PHENYL-1H-PYRAZOLE, 97 is used as a starting material for the development of new drugs. Its potential biological and pharmacological activities are being explored, with the aim of discovering novel therapeutic agents for various diseases and conditions.
Used in Agrochemical Development:
4-BROMO-1-METHYL-5-PHENYL-1H-PYRAZOLE, 97 is also utilized in the agrochemical sector as a precursor for the synthesis of new pesticides and other crop protection agents. Its unique chemical properties enable the development of innovative and effective solutions for agricultural challenges.
Used in Research Applications:
In academic and industrial research settings, 4-BROMO-1-METHYL-5-PHENYL-1H-PYRAZOLE, 97 is employed as a reagent or intermediate in various chemical reactions and experiments. Its high purity and availability make it a reliable choice for researchers working on the synthesis and study of new compounds and their potential applications.

Upstream product

• 74641-60-4 2-methylamino-2-phenylacetic acid 
• 15803-02-8 4-bromo-1-methyl-1H-pyrazole 
• 108-86-1 bromobenzene 
• 3463-27-2 1-methyl-5-phenyl-1H-pyrazole 
• 3463-26-1 1-methyl-3-phenyl-1H-pyrazole 
• 2458-26-6 3-phenylpyrazole 
• 57623-20-8 3-benzoyloxy-1-phenyl-propenone 
• 3506-51-2 Benzoyl acetaldehyde 
• 5443-49-2 α-bromocinnamaldehyde 
• 35431-71-1 3-methyl-4-phenylsydnone 
• 52816-35-0 dimethyl 1-methyl-5-phenylpyrazole-3,4-dicarboxylate 
• 105994-74-9 1-methyl-5-phenylpyrazole-3,4-dicarboxylic acid 
• 13808-65-6 4-bromo-3(5)-phenyl-1H-pyrazole 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 141334-91-0 4,5-diphenyl-1-methylpyrazole 
• 105994-75-0 1-methyl-5-phenyl-1H-pyrazole-4-carboxylic acid 
• 105994-78-3 1-Methyl-5-phenyl-1H-pyrazole-4-carbonyl chloride 
• 80326-71-2 methyl 1-methyl-5-phenyl-1H-pyrazole-4-carboxylate 

Relevant academic research and scientific papers

Direct (Hetero)arylation of Heteroarenes Catalyzed by Unsymmetrical Pd-PEPPSI-NHC Complexes under Mild Conditions

With the aim of developing a facile and efficient method to access structurally intriguing and valuable functionalized (hetero)aryls, two unsymmetrical Pd-PEPPSI-type NHC complexes (PEPPSI, pyridine-enhanced precatalyst preparation, stabilization, and initiation; NHC, N-heterocyclic carbene) were designed and synthesized to catalyze the direct arylation of heteroarenes with (hetero)aryl bromides. The results demonstrated that the utilization of this "unsymmetrical"strategy led to much higher efficiency in comparison to the commonly used C2-symmetric Pd-PEPPSI-type NHC complexes. Furthermore, a broad range of heteroaromatics and (hetero)aryl bromide partners with a wide variety of functional groups were all amenable to the developed protocol even at as low as 0.05 mol % catalyst loading and under aerobic conditions. More importantly, along with our study, we also found that the present protocol could provide expedient access to the gram-scale synthesis of the muscle relaxant drug dantrolene and conjugated mesopolymers.

IMIDAZOPYRIDAZINE COMPOUNDS

The present invention relates to novel substituted imidazo[1,2-b]pyridazine compounds of Formula (I): pharmaceutical compositions thereof, and the use such compounds as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric disorders and neurological diseases.

Benzoyl phenyl 1-methylpyrazoles. Synthesis, characterization, and spectra

The synthesis and unequivocal characterization of all six isomers of benzoyl phenyl 1-methylpyrazole (2) are described.The isomer of 2 isolated as one of the products of the reaction of 1,1-dimethyl-1-phenacylhydrazinium bromide (1) with base was shown to be only previously reported isomer, 5-benzoyl-3-phenyl-1-methylpyrazole (2b).