1380817-91-3Relevant academic research and scientific papers
Amine-mediated tandem conjugative isomerization-bridging Michael addition: Concise synthesis of 1-azabicyclo[3.3.1]nonanes
Ngo, Anh Ngoc,El Kassimi, Khadija,Amara, Zacharias,Drège, Emmanuelle,Joseph, Delphine
, p. 3296 - 3300 (2012/08/08)
To reach densely functionalized 1-azabicyclo[3.3.1]nonane frameworks synthesis, a stereocontrolled bridging Michael addition involving an unexplored C-5/C-6 disconnection strategy was studied. 1-Azabicyclo[3.3.1]nonane scaffolds have been diastereoselectively elaborated in fairly good yields by two concise pathways implying pyrrolidine derivative organocatalyst or enantiopure 1-phenylethylamine.
