1380835-99-3

Upstream product

• 1360624-59-4 N-(4-fluoro-3-chloro-phenyl)-2-fluoro-4-methylamino-5-nitro-benzoic acid amide 
• 57395-89-8 4-fluoropiperidine hydrochloride 
• 1242270-10-5 2-fluoro-4-methylamino-5-nitro-benzoic acid 
• 153775-33-8 2,4-difluoro-5-nitro-benzoic acid 

Downstream Products

• 1380836-00-9 N-(4-fluoro-3-chloro-phenyl)-2-(4-fluoro-piperidinyl)-4-methylamino-5-amino-benzoic acid amide 
• 1380831-23-1 N-(4-Fluoro-3-chloro-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(4-fluoro-piperidinyl)-1-methyl-1H-benzimidazole-5-carboxylic acid amide 

Relevant academic research and scientific papers

NOVEL COMPOUNDS

This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, L, M, W, R1, R2, R3, R4, R6, R7, R9, Ra, Rb have meanings given in the description.

6-AMINO-2-PHENYLAMINO-1H-BENZIMIDAZOLE-5-CARBOXAMIDE- DERIVATIVES AND THEIR USE AS MICROSOMAL PROSTAGLANDIN E2 SYNTHASE-1 INHIBITORS

This invention relates to compounds of formula (I) their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, L, M, W, R1, R2, R3, R4, R6, R7, R9, Ra, Rb have meanings given in the description.