138092-04-3

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 109-72-8 n-butyllithium 
• 109-79-5 n-butanethiol 
• 104-55-2 3-phenyl-propenal 

Downstream Products

• 138092-10-1 2,2-Dimethyl-3-hydroxy-5-(butylthio)-5-phenylpentanoic acid methyl ester 
• 138092-10-1 2,2-Dimethyl-3-hydroxy-5-(butylthio)-5-phenylpentanoic acid methyl ester 
• 1017904-13-0 3-(butylthio)-3-phenylpropan-1-ol 

Relevant academic research and scientific papers

N-Heterocyclic carbene-catalyzed sulfa-Michael addition of enals

An efficient N-heterocyclic carbene (NHC) catalyzed sulfa-Michael addition (SMA) between enals and thiols has been developed. Under the catalysis of 10 mol% stable free carbene IPr and with 20 mol% hexafluoroisopropanol (HFIP) as an additive, enals react with a variety of thiols to afford the SMA adducts in 54-98% yields. In this process, the free carbene preferentially interacts with thiols through hydrogen-bonding and no NHC-catalyzed extended Umpolung transformations were observed.

Hydrochalcogenation of activated olefines. Synthesis of functionalized dialkylchalcogenides

Alkanethiols, selenols and tellurols are generated in situ by reaction of elemental sulfur, selenium and tellurium with commercial alkyllithiums, followed by reaction with deoxygenated water. The alkanechalcogenols react in situ with activated olefins in a Michael-type addition reaction.