138133-34-3

Usage

Uses

(2S,5S)-2,5-Dimethylpyrrolidine Hydrochloride is a reagent used for asymmetric synthesis.

Upstream product

• 113774-91-7 ((R)-1-Methyl-pent-4-enyl)-carbamic acid benzyl ester 
• 136522-02-6 (2S,5S)-2,5-dimethylpyrrolidine-1-carboxylic acid benzyl ester 
• 78329-35-8 2-<(Carbobenzoxy)amino>-5-hexene 
• 57606-70-9 (E)-hex-5-en-2-one oxime 
• 59239-06-4 hex-5-en-2-one oxime 
• 7380-76-9 2-aminohex-5-ene 
• 78329-37-0 trans-N-(Carbobenzyloxy)-2,5-dimethylpyrrolidine 

Downstream Products

• 129539-96-4 (2S-trans)-2,5-Dimethyl-1-<1-oxo-5-(phenylmethoxy)-pentyl>pyrrolidine 
• 114143-77-0 2,5-dimethyl-1-(phenylethynyl)-pyrrolidine 

Relevant academic research and scientific papers

SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS

Disclosed are compounds of formula (I) which are bradykinin B1 receptor (B1R) antagonists. These compounds are useful to treat diseases or relieve adverse symptoms associated with inflammation and pain. The invention encompasses novel compounds and acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases involving inflammation and pain.

Chelating diamide based rate enhancement of intramolecular alkene hydroaminations catalyzed by a neutral Sc(III) complex

(Chemical Equation Presented) Neutral scandium amido complexes are viable catalysts for intramolecular alkene hydroamination. Catalytic activity is strongly coupled to the electronic character of the Sc(III) ligand environment with chelating diamide coord

Diastereoselective synthesis of 2,5-dimethylpyrrolidines and 2,6- dimethylpiperidines by reductive amination of 2,5-hexanedione and 2,6- heptanedione with hydride reagents

The reductive amination of 2,5-hexanedione and 2,6-heptanedione with ammonia and primary amines in the presence of hydride reagents afforded 2,5- dimethylpyrrolidines and 2,6-dimethylpiperidines with variable diastereoselectivity, as the cis/trans ratio was affected by the size of the ring formed and the steric and electronic properties of the nitrogen substituent. Increasing the bulkiness of the nitrogen substituent, the cis pyrrolidines and the trans-piperidines were obtained with enhanced selectivity.

THE SYNTHESIS OF EITHER (+) OR (-) TRANS-2,5-DIMETHYLPYRROLIDINE

Trans-2,5-dimethylpyrrolidine, in either optical series, is prepared starting from D or L-alanine in an efficient and reasonably brief reaction sequence.