138147-15-6Relevant academic research and scientific papers
Decitabine intermediate compound VI
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Paragraph 0025; 0091-0101, (2021/01/24)
The invention belongs to the technical field of chemical synthesis, and provides a decitabine intermediate compound. A preparation route of the decitabine intermediate compound comprises the followingsteps: taking an oxymethyl compound of a hydroxyl group at a 1 site of 2-deoxy-D-ribose as a raw material, protecting a hydroxyl group at a 3 site and a hydroxyl group at a 5 site respectively, then performing acetylation substitution on a 1 site of sugar, and further treating to obtain the compound. The method is simple and convenient to operate, does not need special equipment, is good in product purity and high in yield, and is suitable for industrial production; decitabine is further synthesized by utilizing the compound, so that the stereoselectivity is high, and the purity isgood.
Process for the manufacture of 2-deoxy-D-threo-pentofuranosides, intermediates for their manufacture and their use
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, (2008/06/13)
Disclosed is a process for the manufacture of 2-Deoxy-D-threo-pentofuranosides of formula 1 wherein R1 is an alkyl group having 1 to 4 carbon atoms and R7 is a hydroxy protection group by reacting a 2-deoxy-D-erythro-pentofuranoside of formula 2 wherein R1 is an alkyl group having 1 to 4 carbon atoms, R3 is an alkyl-, aryl-, alkylaryl- or aralkyl-sulfonyl group, either unsubstituted or substituted one or more times by halogen atoms, nitro or alkoxy groups, an imidazolesulfonyl or halosulfonyl group, and R4 has the same meaning as R3 or signifies a hydroxy protection group. Furtheron disclosed are a process for the manufacture of 3-substituted 2-deoxy-D-erythro-pentofuranosides using these compounds and novel and substituted and unsubstituted 2-deoxy-D-pentofuranosides and their use for the manufacture of 3'-substituted 2'-deoxynucleosides.
