138154-62-8Relevant academic research and scientific papers
An approach to α-substituted amines
Williams, Lorenzo,Booth, Susan E.,Undheim, Kjell
, p. 13697 - 13708 (2007/10/02)
A number of amines have been alkylated at the position alpha to nitrogen via free radical methodology. N-(2-iodobenzyl) and N-(2-iodobenzoyl) 'protected' amines have been used to generate radicals which rapidly undergo a 1,5-hydrogen shift to give more st
α-Alkylation of Amines via a 1,5-Hydrogen Shift
Undheim, Kjell,Williams, Lorenzo
, p. 883 - 884 (2007/10/02)
Radicals derived from N-(2-iodobenzyl) 'protected' amines undergo a 1,5-hydrogen shift to give more stable α-amino radicals, which can be subsequently trapped by electron deficient alkenes.
Generation and Alkylation of Carbanions α to the Nitrogen of Amines by a New Metalation Procedure
Murakami, Masahiro,Hayashi, Minoru,Ito, Yoshihiko
, p. 793 - 794 (2007/10/02)
Treatment of a tertiary amine having a pendent o-iodobenzyl group on nitrogen with SmI2 generates α-amino organosamarium, which reacts with electrophiles giving the corresponding C-C bond formation products in good yield.
