138175-26-5Relevant articles and documents
Addition of allylmetal reagents to the imine derived from 2-pyridine carboxaldehyde and methyl (S)-valinate. Synthesis of (S)- and (R)-1-(2-pyridyl)-3-butenamine
Alvaro, Giuseppe,Savoia, Diego
, p. 2083 - 2092 (1996)
Allylmetal reagents add to the imine derived from 2-pyridine carboxaldehyde and methyl (S)-valinate or to preformed imine-metal salt complexes to give mainly the S,S- or the R,S-secondary homoallylic amine, depending on the nature of the allylmetal reagents. Both the (S)- and (R)-1-(2-pyridyl)-3-butenamine were prepared with high enantiomeric purity by removal of the auxiliary group.
A straightforward access to pyrrolidine-based ligands for asymmetric synthesis
Delaye, Pierre-Olivier,Ahari, M'Hamed,Vasse, Jean-Luc,Szymoniak, Jan
experimental part, p. 2505 - 2511 (2011/02/22)
A straightforward and flexible method for the preparation of ligands based on the pyrrolidine scaffold is presented. The synthetic strategy involves a diastereoselective allylation of phenylglycinol-derived imines, followed by a cyclization promoted by a