138175-26-5

Upstream product

• 1121-60-4 pyridine-2-carbaldehyde 
• 3731-51-9 2-(Aminomethyl)pyridine 
• 181867-93-6 (S)-3-Methyl-2-((R)-1-pyridin-2-yl-but-3-enylamino)-butyric acid methyl ester 
• 90472-55-2 methyl N-(2-pyridylmethylidene)-(S)-valinate 
• 182074-28-8 (S)-3-Methyl-2-((R)-1-pyridin-2-yl-but-3-enylamino)-butan-1-ol 
• 138175-30-1 (1S,2S,5S)-2,6,6-Trimethyl-3-[(Z)-1-pyridin-2-yl-but-3-enylimino]-bicyclo[3.1.1]heptan-2-ol 
• 323584-20-9 (1S,2S,5S)-2,6,6-Trimethyl-3-[(Z)-pyridin-2-ylmethylimino]-bicyclo[3.1.1]heptan-2-ol 

Downstream Products

• 1262117-00-9 C₂₈H₂₆N₂ 
• 80220-52-6 (1R,9aR)-1-aminooctahydro-1H-quinolizine 

Relevant academic research and scientific papers

Addition of allylmetal reagents to the imine derived from 2-pyridine carboxaldehyde and methyl (S)-valinate. Synthesis of (S)- and (R)-1-(2-pyridyl)-3-butenamine

Allylmetal reagents add to the imine derived from 2-pyridine carboxaldehyde and methyl (S)-valinate or to preformed imine-metal salt complexes to give mainly the S,S- or the R,S-secondary homoallylic amine, depending on the nature of the allylmetal reagents. Both the (S)- and (R)-1-(2-pyridyl)-3-butenamine were prepared with high enantiomeric purity by removal of the auxiliary group.

A hydrozirconation/iodination-mediated access to tetrahydroquinolizinium salts. Application to the synthesis of Lupinine and (-)-Epiquinamide

The preparation of tetrahydroquinolizinium salts, based on a hydrozirconation/iodination sequence involving 2-pyridyl alkenes, is presented. This approach was applied to the synthesis of substituted quinolizines as illustrated by the synthesis of Lupinine

A straightforward access to pyrrolidine-based ligands for asymmetric synthesis

A straightforward and flexible method for the preparation of ligands based on the pyrrolidine scaffold is presented. The synthetic strategy involves a diastereoselective allylation of phenylglycinol-derived imines, followed by a cyclization promoted by a

Asymmetric Synthesis XV: Enantioselective Syntheses of (R) or (S)-α-Substituted-(2-pyridyl) Methylamines via Chiral Pinanone Ketimine Template

Enantioselective synthesis of (R) or (S)-α-substituted-(2-pyridyl)-methylamines (5), using 2-hydroxypinan-3-one (1) as chiral auxiliary, had been studied.The e.e. values of 5 were 89-98percent, which determined by chiral capillary GC (stationary phase; Chirasil-Val).