138175-50-5

Basic information

• Product Name: 2-CYANO-5-PHENYL-2,4-PENTADIENAMIDE
• Synonyms: 2-CYANO-5-PHENYL-2,4-PENTADIENAMIDE
• CAS NO: 138175-50-5
• Molecular Formula: C₁₂H₁₀N₂O
• Molecular Weight: 198.22
• Mol File: 138175-50-5.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-CYANO-5-PHENYL-2,4-PENTADIENAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CYANO-5-PHENYL-2,4-PENTADIENAMIDE(138175-50-5)
• EPA Substance Registry System: 2-CYANO-5-PHENYL-2,4-PENTADIENAMIDE(138175-50-5)

Safety Data

• Hazardous Substances Data: 138175-50-5(Hazardous Substances Data)

Upstream product

• 104-55-2 3-phenyl-propenal 
• 5439-39-4 1,1-dicyano-4-phenylbuta-1,3-diene 
• 14371-10-9 (E)-3-phenylpropenal 
• 1113-55-9 2-bromo-2-cyanoacetamide 
• 109-77-3 malononitrile 
• 107-91-5 cyanoacetic acid amide 

Relevant articles and documents

Potassium exchanged layered zirconium phosphate as base catalyst in Knoevenagel condensation

Potassium exchanged layered zirconium phosphate catalyzed Knoevenagel condensation of aldehydes and active methylene compounds gave the corresponding E configurated olefinic derivatives in solvent free conditions.

Synthesis of 2-cyanoacrylamides through Pd-catalyzed monohydration of methylenemalononitriles

A straightforward and efficient method has been developed for the synthesis of 2-cyanoacrylamide from 2-methylenemalononitriles through monohydration. A series of methylenemalononitriles underwent the reaction under mild and simple reaction conditions wit

Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach

Based on a known nanomolar Bcl-2 homology domain 3 (BH3) mimetic 3-thiomorpholin-8-oxo-8H-acenaphtho[1,2-b] pyrrole-9-carbonitrile (S1, MW: 331), we applied a fragment-based approach to obtain BH3 mimetics with improved affinity and improved solubility in a water-ethanol (9:1) cosolvent. After the deconstruction of 1 (S1), we obtained fragment cyanoacetamide (4), which was determined to be a ligand efficiency (LE) hot part. After a rational optimization through fragment evolution beginning with fragment 4, a smaller Mcl-1 inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g, MW: 288) with a 6-fold increase in affinity compared to 1 was obtained, as predicted by our optimization curve and identified by Mcl-1 protein nuclear magnetic resonance (NMR).