1381771-01-2Relevant academic research and scientific papers
Synthesis and anti-leishmanial activity of 1-aryl-β-carboline derivatives against Leishmania donovani
Gohil, Vikrantsinh M.,Brahmbhatt, Keyur G.,Loiseau, Philippe M.,Bhutani, Kamlesh K.
, p. 3905 - 3907 (2012/07/03)
β-carbolines from various natural and synthetic sources have been known to show diverse biological activities. As a part of our current ongoing project to search for potent natural product-derived anti-leishmanial compounds, we have synthesized a series of substituted 1-aryl-β-carboline derivatives. A total of 22 compounds were synthesized and tested in vitro against Leishmania donovani, out of which 6 compounds (4, 5, 10, 11, 19 and 22) showed notably more activity than the standard miltefosine (IC50 12.07 ± 0.82 μM), with compound 4 being the most potent (IC 50 2.16 ± 0.26 μM).
