771533-61-0

Upstream product

• 54-12-6 Trp 
• 24243-44-5 1-(4-nitrophenyl)-9H-pyrido[3,4-b]indole 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 1381771-03-4 N-(4-(9H-pyrido[3,4-b]indol-1-yl)phenyl)furan-2-carboxamide 
• 1381771-01-2 N-(4-(9H-pyrido[3,4-b]indol-1-yl)phenyl)thiophene-2-carboxamide 
• 1381771-13-6 N-(4-(9H-pyrido[3,4-b]indol-1-yl)phenyl)-2,5-dimethylfuran-3-carboxamide 
• 1381771-11-4 N-(4-(9H-pyrido[3,4-b]indol-1-yl)phenyl)dodecanamide 
• 1381771-05-6 N-(4-(9H-pyrido[3,4-b]indol-1-yl)phenyl)undec-10-enamide 
• 1381771-15-8 N-(4-(9H-pyrido[3,4-b]indol-1-yl)phenyl)-4-cyanobenzamide 
• 1381771-14-7 N-(4-(9H-pyrido[3,4-b]indol-1-yl)phenyl)-4-(trifluoromethyl)benzamide 
• 1381771-07-8 N-(4-(9H-pyrido[3,4-b]indol-1-yl)phenyl)-3,4-difluorobenzamide 
• 1381771-04-5 N-(4-(9H-pyrido[3,4-b]indol-1-yl)phenyl)benzamide 
• 1381771-09-0 N-(4-(9H-pyrido[3,4-b]indol-1-yl)phenyl)-4-methylbenzamide 
• 1381771-06-7 N-(4-(9H-pyrido[3,4-b]indol-1-yl)phenyl)-2,4-difluorobenzamide 
• 1381771-10-3 N-(4-(9H-pyrido[3,4-b]indol-1-yl)phenyl)pentanamide 
• 771533-59-6 N-(4-(9H-pyrido[3,4-b]indol-1-yl)phenyl)acetamide 
• 1381771-02-3 N-(4-(9H-pyrido[3,4-b]indol-1-yl)phenyl)tetradecanamide 

Relevant academic research and scientific papers

Synthesis and anti-leishmanial activity of 1-aryl-β-carboline derivatives against Leishmania donovani

β-carbolines from various natural and synthetic sources have been known to show diverse biological activities. As a part of our current ongoing project to search for potent natural product-derived anti-leishmanial compounds, we have synthesized a series of substituted 1-aryl-β-carboline derivatives. A total of 22 compounds were synthesized and tested in vitro against Leishmania donovani, out of which 6 compounds (4, 5, 10, 11, 19 and 22) showed notably more activity than the standard miltefosine (IC50 12.07 ± 0.82 μM), with compound 4 being the most potent (IC 50 2.16 ± 0.26 μM).