1381773-89-2Relevant academic research and scientific papers
Anti-selective direct catalytic asymmetric aldol reaction of thiolactams
Sureshkumar, Devarajulu,Kawato, Yuji,Iwata, Mitsutaka,Kumagai, Naoya,Shibasaki, Masakatsu
supporting information; experimental part, p. 3108 - 3111 (2012/08/07)
An anti-selective direct catalytic asymmetric aldol reaction of thiolactam is described. A soft Lewis acid/hard Br?nsted base cooperative catalyst comprised of mesitylcopper/(R,R)-Ph-BPE exhibited high catalytic performance to produce an anti-aldol product with high stereoselectivity. The highly chemoselective nature of the present catalysis allows for the use of enolizable aldehydes as aldol acceptors. The diverse transformations of the thiolactam moiety highlight the synthetic utility of the present anti-aldol protocol.
