1381789-61-2

Basic information

• Product Name: Fmoc-(p-terphenyl)alanine
• Synonyms: Fmoc-(p-terphenyl)alanine
• CAS NO: 1381789-61-2
• Molecular Weight: 539.631
• Mol File: 1381789-61-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Fmoc-(p-terphenyl)alanine(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-(p-terphenyl)alanine(1381789-61-2)
• EPA Substance Registry System: Fmoc-(p-terphenyl)alanine(1381789-61-2)

Safety Data

• Hazardous Substances Data: 1381789-61-2(Hazardous Substances Data)

Upstream product

• 60-18-4 L-tyrosine 
• 1080-06-4 L-Tyr-OMe 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 
• 112766-18-4 methyl N-(tert-butoxycarbonyl)-O-[(trifluoromethyl)sulfonyl]-L-tyrosinate 
• 643016-66-4 N-(tert-butoxycarbonyl)-4[(4’;1’,1”)biphenyl]-L-phenylalanine methyl ester 

Relevant articles and documents

Synthesis and biological evaluation of tyrosine modified analogues of the α4β7 integrin inhibitor biotin-R8ERY

The α4β7 integrin is a well-known target for the development of drugs against various inflammatory disease states including inflammatory bowel disease, type 1 diabetes and multiple sclerosis. The synthesis of a small library of cell-permeable β7 integrin inhibitors based on the peptide biotin-R8ERY is reported, in which the tyrosine residue has been modified by using the Suzuki-Miyaura cross-coupling reaction. The synthesised peptidomimetics were evaluated in a cell adhesion assay and shown to inhibit Mn2+-activated adhesion of mouse TK-1 T cells to mouse MAdCAM-1. All of the synthesised peptidomimetics are more active than our previously reported lead compound biotin-R8ERY with two of the analogues, 6 and 7, exhibiting IC50 values of 15 μM.