1381802-65-8Relevant academic research and scientific papers
Approaches to the construction of substituted 4-amino-1 H -pyrrol-2(5 H)-ones
Zali-Boeini, Hassan,Mobin, Mehdi,Hajibabaei, Khadijeh,Ghani, Maryam
experimental part, p. 5808 - 5812 (2012/07/31)
Fully substituted 4-aminopyrrolones are easily accessed via simple routes starting from imines, ketones, or α-bromophenyl acetonitriles. Imines were reacted with KCN/NH4Cl in aqueous ethanol to produce α-arylamino benzyl cyanides. On the other hand, ketones were transformed to the desired α-amino nitriles using a modified Strecker reaction. Then, α-amino nitrile precursors were allowed to react with a suitable acyl halide to produce the corresponding amides. Further treatment of these amides with ethanolic KOH converted them to highly substituted 4-amino-1H-pyrrol-2(5H)- one derivatives in moderate to excellent yields.
