5918-69-4

Upstream product

• 106-49-0 p-toluidine 
• 636-72-6 2-thiophenemethanol 
• 104239-21-6 N-(p-mrthylphenyl)-2-thiophenecarbimidoyl chloride 
• 98-03-3 thiophene-2-carbaldehyde 

Downstream Products

• 70454-03-4 3r-methoxy-4c-thiophen-2-yl-1-p-tolyl-azetidin-2-one 
• 70454-06-7 3r-phenoxy-4c-thiophen-2-yl-1-p-tolyl-azetidin-2-one 
• 105090-48-0 1-(4-Methylphenyl)-3,3-diphenyl-4(2-thienyl)-2-azetidinone 
• 1000405-92-4 3,5-diphenyl-2-(thiophen-2-yl)-1-(p-tolyl)-1H-pyrrole 
• 914461-19-1 [Cu(o-hydroxyacetophenoneglycine^(2-))(thiophene-o-carboxaldene-p-toluidine)(H₂O)] 
• 1618085-20-3 dimethyl N-(p-methylphenyl)amino(2-thienyl)methylphosphonate 
• 1381802-65-8 4-amino-3-phenyl-5-(thiophen-2-yl)-1-p-tolyl-1H-pyrrol-2(5H)-one 
• 1381803-79-7 C₂₁H₁₈N₂OS 
• 1381802-70-5 4-amino-5-(anthracen-10-yl)-3-phenyl-1-p-tolyl-1H-pyrrol-2(5H)-one 
• 461443-86-7 C₁₃H₁₂N₂S 
• 914461-21-5 [Cd(o-hydroxyacetophenoneglycine^(2-))(thiophene-o-carboxaldene-p-toluidine)(H₂O)] 
• 914461-20-4 [Zn(o-hydroxyacetophenoneglycine^(2-))(thiophene-o-carboxaldene-p-toluidine)(H₂O)] 
• 914461-16-8 [Mn(o-hydroxyacetophenoneglycine^(2-))(thiophene-o-carboxaldene-p-toluidine)(H₂O)] 
• 927189-76-2 [Co(salicylidene-DL-alanine(-2H))(thiophene-o-carboxaldene-p-toluidine)(H₂O)] 

Relevant academic research and scientific papers

Cationic allylnickel(II) complexes bearing labile N,S-donor ligands: Synthesis, characterization and crystal structure

The thienylimine ligands2,6-dimethyl-N-(thiophen-2-ylmethylene)aniline (L1), 2,6-diisoprop yl-N-(thiophen-2-ylmethylene)aniline (L2) and 4-methyl-N-(thiophen-2-ylmethylene)aniline (L3) were obtained by condensation reactions of 2-formyl thiophene with the

Effect of new thiophene-derived aminophosphonic derivatives on growth of terrestrial plants. Part 2. Their ecotoxicological impact and phytotoxicity test toward herbicidal application in agriculture

Background: The aim of this work was to evaluate phytotoxicity of the thiophene derivatives against three persistent weeds of a high degree of resistance (Galinsoga parviflora Cav., Rumex acetosa L., and Chenopodium album) as well as their ecotoxicological impact on Heterocypris incongruens. In addition, Aliivibrio fischeri was measured. Two of eight described aminophosphonates, namely dimethyl N-(2-methoxyphenyl)amino(2-thienyl)methylphosphonate (2d) and dimethyl N-(tert-butyl)- (2-thienyl)methylphosphonate (2h), have never been reported before. Methods: The phytotoxicity of tested aminophosphonates toward their potential application as soil-applied herbicides was evaluated according to the OECD 208 Guideline. Ecotoxicological properties of investigated compounds were made using the OSTRACODTOXKITTM and Microtox tests. Results: Obtained results showed that four aminophosphonates have interesting herbicidal properties and N-(2-methylphenyl)amino- (2-thienyl)methylphosphonate (2a) was found to kill efficiently the most resistant plant Chenopodium album. None of the tested compounds showed important toxicity against Aliivibrio fischeri. However, their toxic impact on Heterocypris incongruens was significantly elevated. Conclusions: The aminophosphonate 2a showed herbicidal potential and it is not toxic against tested bacteria (EC50 over 1000 mg/L). It was found to be moderately toxic against ostracods [mortality 48% at 10 mg/kg of soil dry weight (s.d.w.)] and this problem should be solved by the use of the controlled release from a polymeric carrier.

Reactions of 2,2,6-Trimethyl-1,3-dioxin-4-one with the Aryl Aldimines Prepared from Thiophene-2-carbaldehyde

The reactions of aryl aldimines derived from thiophene-2-carbaldehyde (5–9) with 2,2,6-trimethyl-1,3-dioxin-4-one (1) were investigated. The new 1,3-oxazin-4-ones and thienylidene acetoacetamides were obtained in good yields. The synthetic utility of the latter via an intramolecular tandem Friedel–Crafts alkylation–acylation to give tetracyclic heterocyclic rings was also explored.

Copper-Catalyzed Cascade Reaction via Intramolecular Hydroamination Cyclization of Homopropargylic Amines and Intermolecular Povarov Reaction with Imines

A new one-pot cascade reaction of homopropargylic amines with simple imines is developed in the presence of Cu(OTf)2 and affords a series of hexahydro-1H-pyrrolo[3,2-c]quinoline derivatives in good to high yields. This reaction proceeds through

The effect of new thiophene-derived aminophosphonic derivatives on growth of terrestrial plants: A seedling emergence and growth test

The aim of this work was to synthesize selected thiophene-derived aminophosphonic systems and evaluate the phytotoxicity of newly obtained products according to the OECD 208 Guideline. Seven new thiophene-derived N-substituted dimethyl aminomethylphosphonic acid esters 2a-h were synthesized by the addition of an appropriate phosphite to azomethine bond of starting Schiff bases 1a-h, and NMR spectroscopic properties of aminophosphonates were investigated. These eight compounds were analyzed in regard to their phytotoxicity towards two plants, radish (Raphanus sativus) and oat (Avena sativa). On the basis of the obtained results, it was found that tested aminophosphonates 2a-h showed an ecotoxicological impact against selected plants, albeit to various degrees.

Divergent Coupling of Alcohols and Amines Catalyzed by Isoelectronic Hydride MnIand FeIIPNP Pincer Complexes

Herein, we describe an efficient coupling of alcohols and amines catalyzed by well-defined isoelectronic hydride MnIand FeIIcomplexes, which are stabilized by a PNP ligand based on the 2,6-diaminopyridine scaffold. This reaction is an environmentally benign process implementing inexpensive, earth-abundant non-precious metal catalysts, and is based on the acceptorless alcohol dehydrogenation concept. A range of alcohols and amines including both aromatic and aliphatic substrates were efficiently converted in good to excellent isolated yields. Although in the case of Mn selectively imines were obtained, with Fe—exclusively monoalkylated amines were formed. These reactions proceed under base-free conditions and required the addition of molecular sieves.

Evaluation of N-(2-thienylidene)amines, N-(2-hydroxybenzylidene)amines and 3-iminoindolin-2-ones as antileishmanial agents

The paper describes the synthesis and antileishmanial activity of N-substituted imines, obtained from the reactions of primary amines with three biologically important aldehydes/ketones, thiophene-2-carbaldehyde, 2- hydroxybenzaldehyde (salicylaldehyde) and indoline-2,3-dione. Of the fourteen compounds screened from three classes, five compounds showed significant antileishmanial activity. Among the three classes of imines, the class of N-(2- thienylidene)amines showed much better activity than the other two classes. N-(2-Thienylidene)benzhydrylamine showed IC50 value of 0.51 μg/ml. The effect of substituents on the bioactivity is discussed.

Characterization and antifungal study of genuine oxovanadium(IV) mixed-ligand complexes with schiff bases

New oxovanadium(IV) complexes [VO(L)(A)] (KHL = potassium salt of o-hydroxy-acetophenoneglycine, A1 = 2,2′-bipyridylamine, A 2 = bis(benzylidene)ethylenediamine, A3 = thiophene-o-carboxaldeneaniline, A4 = thioph

Simple and High Yield Synthesis of Aldimines via Palladium Complex-Catalyzed Reduction of Imidoyl Chlorides

Imidoyl chlorides 1 were efficiently reduced to aldimines 2 by molecular hydrogen in the presence of triethylamine and a catalytic amount of bispalladium dichloride