1381843-60-2Relevant academic research and scientific papers
Synthesis of diversely 1,3,5-trisubstituted pyrazoles via 5-exo-dig cyclization
Borkin, Dmitry A.,Puscau, Mirela,Carlson, Alena,Solan, Agnes,Wheeler, Kraig A.,Toeroek, Bela,Dembinski, Roman
supporting information; experimental part, p. 4505 - 4508 (2012/07/17)
5-Exo-dig cyclocondensation of alk-3-yn-1-ones with hydrazines, in the presence of montmorillonite K-10, provides an effective method with a high atom economy for the synthesis of diversely 1,3,5-trisubstituted pyrazoles. The microwave-accelerated reaction proceeds in the absence of solvent and leads to 5-benzyl substituted pyrazoles with good yields (72-91%). The regiochemistry of the process was confirmed by the X-ray crystallographic structure determination of 1-(2-fluorophenyl)-5-(4-methylbenzyl)-3-phenyl-1H-pyrazole.
