1381886-47-0Relevant articles and documents
Stereocontrolled synthesis of piperidine alkaloids, (-)-241D and (-)-isosolenopsin
Murali,Chandrasekhar
scheme or table, p. 3467 - 3470 (2012/08/08)
Highly diastereocontrolled synthesis of alkaloids, (-)-241D and (-)-isosolenopsin was achieved in 7.7% and 5.3% yields, respectively, using a Barbier-type allylation of a chiral imine and d-proline catalyzed aldol addition reaction of a β-amino aldehyde with acetone as the key steps. The synthesis involves a nine-step sequence using (S)-valinate imine in a Barbier-type allylation for the first time.