1381945-64-7

Basic information

• Product Name: C₂₇H₃₄N₈O₁₇P₂
• CAS NO: 1381945-64-7
• Molecular Weight: 804.558
• Mol File: 1381945-64-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₇H₃₄N₈O₁₇P₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₃₄N₈O₁₇P₂(1381945-64-7)
• EPA Substance Registry System: C₂₇H₃₄N₈O₁₇P₂(1381945-64-7)

Safety Data

• Hazardous Substances Data: 1381945-64-7(Hazardous Substances Data)

Upstream product

• 912921-33-6 6-azide-6-deoxy-β-L-galactopyranos-1-yl-guanosine 5'-diphosphate 
• 1381944-92-8 guanosine 5'-diphospho-6-amino-β-L-fucopyranoside 
• 60875-16-3 4-(3-methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid 
• 86-01-1 Guanosine 5'-triphosphate 
• 138332-00-0 6-Azido-β-L-fucose 

Relevant articles and documents

Chemoenzymatic synthesis of GDP-L-fucose derivatives as potent and selective α-1,3-fucosyltransferase inhibitors

Fucosyltransferases (FucTs) usually catalyze the final step of glycosylation and are critical to many biological processes. High levels of specific FucT activities are often associated with various cancers. Here we report the development of a chemoenzymatic method for synthesizing a library of guanosine diphosphate β-L-fucose (GDP-Fuc) derivatives, followed by in situ screening for inhibitory activity against bacterial and human α-1,3-FucTs. Several compounds incorporating appropriate hydrophobic moieties were identified from the initial screening. These were individually synthesized, purified and characterized in detail for their inhibition kinetics. Compound 5 had a Ki of 29 nM for human FucT-VI, and is 269 and 11 times more selective than for Helicobacter pylori FucT (Ki=7.8 μM) and for human FucT-V (Ki=0.31 μM). Copyright