138332-00-0

Basic information

• Product Name: 6-azido-6-deoxy-beta-L-idopyranose
• Synonyms: 6-Azido-6-deoxy-beta-L-idopyranose; beta-L-idopyranose, 6-azido-6-deoxy-
• CAS NO: 138332-00-0
• Molecular Formula: C₆H₁₁N₃O₅
• Molecular Weight: 205.1686
• Mol File: 138332-00-0.mol
• Article Data: 34

Chemical Properties

• CAS DataBase Reference: 6-azido-6-deoxy-beta-L-idopyranose(CAS DataBase Reference)
• NIST Chemistry Reference: 6-azido-6-deoxy-beta-L-idopyranose(138332-00-0)
• EPA Substance Registry System: 6-azido-6-deoxy-beta-L-idopyranose(138332-00-0)

Safety Data

• Hazardous Substances Data: 138332-00-0(Hazardous Substances Data)

Upstream product

• 26391-80-0 6-O-Tosyl-α-D-glucopyranose 
• 475482-64-5 (R)-1-((3aR,5R,6S,6aR)-2,2-dimethyl-6-(naphthalen-2-ylmethoxy)tetrahydrofuro[2,3-d][1,3]dioxol-5-yl)ethane-1,2-diol 
• 159353-63-6 (3aR,5R,6S,6aR)-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyl-6-(naphthalen-2-ylmethoxy)tetrahydrofuro[2,3-d][1,3]dioxole 
• 582-52-5 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose 
• 40789-24-0 methyl 2,3-O-isopropylidene-6-O-p-toluenesulfonyl-α-D-mannofuranoside 
• 212484-29-2 (1,2:3,4-di-O-isopropylidene-6-deoxyazido)-α-D-galactopyranose 
• 4711-00-6 6-azido-6-deoxy-1,2:3,4-di-O-isopropylidene-D-galactopyranose 
• 4064-06-6 1,2:3,4-di-O-isopropylidene-α-D-galactopyranose 
• 57-50-1 Sucrose 
• 40984-16-5 6,6'-dichloro-6,6'-didesoxysaccharose 
• 26275-20-7 6-deoxy-1,2-O-isopropylidene-6-(4'-methylbenzene)sulfonyloxy-D-glucofuranose 
• 18549-40-1 1,2-O-isopropylidene-α-D-glucofuranose 
• 2280-44-6 D-Glucose 
• 23701-87-3 methyl 6-azido-6-deoxy-α-D-glucopyranoside 

Downstream Products

• 212483-93-7 (3R,4S,5R,6S)-3,4,5,6-tetrahydroxyazepine 
• 1381945-53-4 C₂₃H₂₉IN₆O₁₆P₂ 
• 1381945-52-3 C₂₃H₂₉IN₆O₁₆P₂ 
• 1381945-51-2 C₂₃H₂₉BrN₆O₁₆P₂ 
• 1381945-50-1 C₂₃H₂₉ClN₆O₁₆P₂ 
• 1381945-49-8 C₂₄H₃₂N₆O₁₆P₂ 
• 1381945-48-7 C₂₄H₃₂N₆O₁₆P₂ 
• 1381945-47-6 C₂₄H₃₂N₆O₁₆P₂ 
• 1381945-46-5 C₂₃H₃₀N₆O₁₆P₂ 
• 1381945-78-3 C₂₅H₃₂N₆O₁₆P₂ 
• 1381945-77-2 C₂₅H₃₁ClN₆O₁₆P₂ 
• 1381945-76-1 C₂₅H₃₁ClN₆O₁₆P₂ 
• 1381945-75-0 C₂₆H₃₁F₃N₆O₁₆P₂ 
• 1381945-74-9 C₂₄H₃₂N₆O₁₇P₂ 

Relevant articles and documents

Chemo-Enzymatic Synthesis of S. mansoni O-Glycans and Their Evaluation as Ligands for C-Type Lectin Receptors MGL, DC-SIGN, and DC-SIGNR

Due to their interactions with C-type lectin receptors (CLRs), glycans from the helminth Schistosoma mansoni represent promising leads for treatment of autoimmune diseases, allergies or cancer. We chemo-enzymatically synthesized nine O-glycans based on th

Importance of topology for glycocluster binding to Pseudomonas aeruginosa and Burkholderia ambifaria bacterial lectins

Pseudomonas aeruginosa (PA) and Burkholderia ambifaria (BA) are two opportunistic Gram negative bacteria and major infectious agents involved in lung infection of cystic fibrosis patients. Both bacteria can develop resistance to conventional antibiotherap

Curdlan as a polymeric starting material to access C6-modified glucose derivatives

We evaluated the potential of a linear β-1,3-glucan (curdlan) as a starting material to access C6-modified glucose derivatives and found that 6-bromo-6-deoxyglucose, 6-azide-6-deoxyglucose, and 6-acetamido-6-deoxyglucose could be readily prepared from curdlan through its C6-selective and quantitative modifications and subsequent acid-catalyzed hydrolysis.

Metallization of double-stranded DNA triggered by bound galactose-modified naphthalene diimide

Naphthalene diimide (NDI) derivatives bearing galactose moieties through different spacers, NDI-DS1 and NDI-DS2, were synthesized by the click reaction of the acetylene derivatives of NDI with galactose azide. They bound to double-stranded DNA with threading intercalation, as confirmed by the topoisomerase I assay and circular dichroism spectroscopy. The binding affinities of these ligands were on the order of 105 M-1 with several-fold higher affinity for double-stranded DNA than for single-stranded DNA. The silver mirror reaction on the double-stranded DNA bound to these ligands afforded silver nanowires that were converted to gold nanowires. In the atomic force microscopy measurements, the increased height of DNA areas on a mica plate was observed in the case of double-stranded DNA after NDI-DS2 treatment and subsequently silver mirror reaction, whereas the increased height of DNA areas was not observed in the case of single-stranded DNA after the same treatment.

Novel 1,2,3-triazole-tethered Pam3CAG conjugates as potential TLR-2 agonistic vaccine adjuvants

A focused library of water soluble 1,2,3-triazole tethered glycopeptide conjugates derived from variety of azido-monosaccharides and aliphatic azido-alcohols were synthesized through manipulation at the C-terminus of Pam3CAG and screened for their potential as TLR2 agonistic adjuvants against HBsAg antigen. In vitro ligand induced TLR2 signal activation was observed with all the analogues upon treatment with HEK blue TLR2 cell lines. Conjugate derived from ribose (6e), which exhibited pronounced HBsAg specific antibody (IgG) titer also shown enhanced CD8+ population indicating superior cell mediated immunity compared to standard adjuvant Pam3CSK4. Further, docking studies revealed ligand induced heterodimerization between TLR1 and 2. Overall, the result indicates the usefulness of novel conjugates as potential vaccine adjuvant.

A FUNCTIONALIZED GLYCOLIPID AND AN APPLICATION THEREOF

The present invention discloses a functionalized glycolipid having a formula (I): (I) where Y is selected from a group consisting of O, NH and NAc; wherein A is selected from a group of bi-antennary hydrophobic domain having a formula (II): (II) and mono-antennary hydrophobic domain having a formula (III): (III) wherein B having a formula (IV): (IV). Further, the present invention discloses an application of the functionalized glycolipid having the formula (I) thereof. The functionalized glycolipid is usable with a drug delivery carrier for binding biological recognition domain for the cells specific recognition of the carrier via click chemistry.