1381980-76-2Relevant articles and documents
Highly Selective Synthesis of 2-(2 H-1,2,3-Triazol-2-yl)benzoic Acids
Roth, Remo,Schmidt, Gunther,Prud'homme, Alice,Abele, Stefan
, p. 234 - 243 (2019/02/01)
A selective and scalable synthesis of 2-(2H-1,2,3-triazol-2-yl)benzoic acid starting from 1-fluoro-2-nitrobenzene derivatives is presented. The four-step synthesis introduces the triazole at the start via N2-arylation of 4,5-dibromo-2H-1,2,3-triazole. A sequence of consecutive functional group transformations, namely hydrogenation, Sandmeyer iodination, and Grignard carboxylation, provides the target molecules in a reliable and scalable manner. The usefulness of this method is demonstrated by the synthesis of di-or tri(2H-1,2,3-triazol-2-yl)benzene derivatives, which are difficult to produce by other methods.
Highly selective synthesis of 2-(2H-1,2,3-Triazol-2-yl)benzoic acids
Roth, Remo,Schmidt, Gunther,Prudhomme, Alice,Abele, Stefan
, p. 234 - 243 (2019/08/26)
A selective and scalable synthesis of 2-(2H-1,2,3-triazol-2-yl)benzoic acid starting from 1-fluoro-2-nitrobenzene derivatives is presented. The four-step synthesis introduces the triazole at the start via N2-arylation of 4,5-dibromo-2H-1,2,3- triazole. A sequence of consecutive functional group transformations, namely hydrogenation, Sandmeyer iodination, and Grignard carboxylation, provides the target molecules in a reliable and scalable manner. The usefulness of this method is demonstrated by the synthesis of di- or tri(2H-1,2,3-triazol-2-yl)benzene derivatives, which are difficult to produce by other methods.
PREPARATION OF 2-([1,2,3]TRIAZOL-2-YL)-BENZOIC ACID DERIVATIVES
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, (2018/11/26)
The present invention relates to a process for the preparation of particular 2-(2H-[1,2,3]triazol-2-yl)-benzoic acid derivatives of formula (I), to certain crystalline forms of potassium salts of said 2-(2H-[1,2,3]triazol-2-yl)-benzoic acid derivatives of formula (IK), to certain crystalline forms of said 2-(2H-[1,2,3]triazol-2-yl)-benzoic acid derivatives of formula (I), and to their use in the preparation of pharmaceuticals such as (S)-(2-(5-chloro-4-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)-(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone.
Regioselective halogenation of 2-substituted-1,2,3-triazoles via sp 2 C-H activation
Tian, Qingshan,Chen, Xianmin,Liu, Wei,Wang, Zechao,Shi, Suping,Kuang, Chunxiang
, p. 7830 - 7833 (2013/11/19)
A highly regioselective halogenation of 2-substituted-1,2,3-triazoles was developed via sp2 C-H activation. This method is compatible with halogen atoms, as well as electron-donating and electron-withdrawing groups. Meanwhile, the strategy is a
Deproto-metallation and computed CH acidity of 2-aryl-1,2,3-triazoles
Chevallier, Floris,Blin, Thomas,Nagaradja, Elisabeth,Lassagne, Frédéric,Roisnel, Thierry,Halauko, Yury S.,Matulis, Vadim E.,Ivashkevich, Oleg A.,Mongin, Florence
experimental part, p. 4878 - 4885 (2012/07/28)
2-Aryl-1,2,3-triazoles were synthesized by cyclization of the corresponding glyoxal arylosazones, generated from commercial arylhydrazines. The deproto-metallation of 2-phenyl-1,2,3-triazole was attempted using different 2,2,6,6-tetramethylpiperidino-based mixed lithium-metal (Zn, Cd, Cu, Co, Fe) combinations, giving results in the case of Zn, Cd, and Cu. The lithium-zinc combination was next selected to apply the deprotonation-iodination sequence to all the 2-aryl-1,2,3-triazoles synthesized. The results were analyzed with the help of the CH acidities of the substrates, determined in THF solution using the DFT B3LYP method.
