138201-07-7Relevant academic research and scientific papers
Horner-Wadsworth-Emmons olefination of nonstabilized phosphonates. A new synthetic approach to β,γ-unsaturated amides
Janecki,Janecki, Tomasz,Bodalski,Bodalski, Ryszard,Wieczorek,Wieczorek, Michakl,Bujacz,Bujacz, Grzegorz
, p. 1721 - 1740 (2007/10/02)
Aminolysis of readily accessible β-diethoxyphosphonyl-γ-butyrolactones 5 and 22 provides a convenient entry to (E)-β,γ-unsaturated amides 8 and 24 respectively. The key step of the aminolysis involves elimination of diethoxyphosporic acid from the corresp
β-Diethoxyphosphorylpropionic acid, a convenient reagent for the synthesis of β,δ - unsaturated amides
Janecki, Tomasz,Bodalski, Ryszard
, p. 6231 - 6234 (2007/10/02)
β-Diethoxyphosphorylpropionic acid (1) is converted into δ-substituted β-(diethoxyphosphoryl)-δ-lactones 5 by LDA promoted reaction with carbonyl compounds 3. Aminolysis or alternatively a standard alkylation and aminolysis of 5 afford (E)- β,δ-imsaturated amides 7 or 10 in good yield.
