138203-03-9

Upstream product

• 22692-94-0 α-fluorophenylacetic acid chloride 
• 538-51-2 benzylidene phenylamine 
• 138202-88-7 Fluoro-phenyl-acetic acid 2,4,6-trimethyl-phenyl ester 
• 108-86-1 bromobenzene 

Relevant academic research and scientific papers

Ni-catalyzed α-arylation of secondary α-bromo-α-fluoro- β-lactam: Cross-coupling of a secondary fluorine-containing electrophile

A highly diastereoselective cross-coupling reaction of an α-bromo-α-fluoro-β-lactam with a wide range of aryl Grignard reagents was catalyzed by Ni/bis(oxazoline) in yields of up to 98%. The product was obtained diastereoselectively as an anti-isomer. This is the first successful α-arylation of an α-fluoro-β-lactam to produce diverse α-aryl-α-fluoro-β-lactams.

The Stereoselective Synthesis of 3-Fluoro-azetidinones

3-Fluoro-azetidinones were prepared by both the enolate-imine and ketene-imine condensation reactions.The reactions of fluorinated ketenes with imines were remarkably stereoselective forming products derived from lk reaction topicity.Key Words: β-Lactams;