22692-94-0Relevant articles and documents
AZABICYCLO AND DIAZEPINE DERIVATIVES FOR TREATING OCULAR DISORDERS
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, (2019/05/22)
The present invention provides in one aspect azabicycio and diazepine derivatives useful as modulators of muscarinic receptors. In another aspect, the present invention provides pharmaceutical compositions for treating ocular diseases, the compositions comprising at least one muscarinic receptor modulator. Formulae (I) & (II):
The in situ generation and trapping of some fluorine-substituted ketenes
Dolbier Jr., William R.,Lee, Suk Kyu,Phanstiel IV, Otto
, p. 2065 - 2072 (2007/10/02)
Fluoroketene, difluoroketene, methylfluoroketene, trifluoromethylfluoroketene, and phenylfluoroketene were each generated, in situ, via dehydrohalogenation of the respective acid chlorides. In the presence of cyclopentadiene [2 + 2] adducts were obtained in all but the difluoroketene case. In the absence of cyclopentadiene, low temperature 19F nmr indicated the presence of acyl ammonium salts and enolates, potential precursors of the ketenes, but no actual ketene species could unambiguously be detected. The stereochemical results were consistent with the currently accepted steric-based mechanistic rationale for stereochemical determination in ketene cycloadditions.
Fluorinated organic compounds with potential biological activity. VII. (1) N-substituted amides of alpha-fluoroarylacetic acid
Cavalleri,Sardi
, p. 809 - 821 (2007/10/06)
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