138206-50-5

Upstream product

• 288-32-4 1H-imidazole 
• 56986-82-4 α,α-dibromo-o-hydroxyacetophenone 
• 118-93-4 o-hydroxyacetophenone 
• 2491-36-3 2-(2-bromoacetyl)hydroxybenzene 
• 138206-46-9 (E)-1-<1-(2-Hydroxyphenyl)-2-(methylthio)ethenyl>-1H-imidazole 

Downstream Products

• 138206-85-6 1-[(Z)-1-(2-Hexyloxy-phenyl)-2-methylsulfanyl-vinyl]-1H-imidazole 
• 138206-84-5 1-[(Z)-2-Methylsulfanyl-1-(2-pentyloxy-phenyl)-vinyl]-1H-imidazole 
• 138206-83-4 1-[(Z)-1-(2-Butoxy-phenyl)-2-methylsulfanyl-vinyl]-1H-imidazole 

Relevant academic research and scientific papers

Preparation method of neticonazole hydrochloride

The invention discloses a preparation method of neticonazole hydrochloride. The preparation method comprises the following steps: (1) taking a compound as shown in a formula III and bromopentane as reaction raw materials, reacting under an alkaline condition, extracting a product obtained by the reaction, reacting the extracted and separated organic product with hydrogen chloride to form a salt soas to obtain neticonazole hydrochloride; optionally (2) refining the obtained neticonazole hydrochloride. According to the method disclosed by the invention, the reaction conditions for preparing each intermediate, the intermediate post-treatment process and the neticonazole hydrochloride refining process are strictly controlled, so that the prepared neticonazole hydrochloride is high in purity,very low in residual solvent and impurity content, and excellent in stability.

Synthesis and antifungal activities of a series of (1,2-disubstituted vinyl)imidazoles

A series of vinylimidazoles containing a hetero atom such as sulfur or oxygen at a β-position of the vinyl group was prepared and the antifungal activities were tested. It was found that sulfur-substituted derivatives such as (E)-1-[2-(methylthio)-1-[2-(p