138208-14-7Relevant academic research and scientific papers
Polyols of a Cascade Type as a Water-Solubilizing Element of Carborane Derivatives for Boron Neutron Capture Therapy
Nemoto, Hisao,Wilson, J. Gerald,Nakamura, Hiroyuki,Yamamoto, Yoshinori
, p. 435 (1992)
A practical method for the synthesis of polyols of a cascade type, as a water-solubilizing element of carborane derivatives for boron neutron capture therapy (BNCT), was developed.The carborane attached to the tetraol 6a was dissolved in water in a concentration of 5.44 M.
Original synthesis of linear, branched and cyclic oligoglycerol standards
Cassel, Stephanie,Debaig, Catherine,Benvegnu, Thierry,Chaimbault, Patrick,Lafosse, Michel,Plusquellec, Daniel,Rollin, Patrick
, p. 875 - 896 (2007/10/03)
A variety of authentic standards of linear, branched and cyclic oligomers of glycerol, with well-defined structures and degrees of polymerisation from 2 to 5, have been efficiently synthesised. Linear oligomers were obtained by means of a convergent approach based on regioselective opening of bis(epoxides) with solketal; branched compounds were synthesised using oxidative cleavage of the corresponding anhydrohexitols as the key step. A 6-exo-trig halocyclisation reaction involving heteroatom-tethered unsaturated alcohols permitted an efficient synthesis of the precursors of selected cyclic dimers; larger cyclic oligomers were prepared by two one-pot Williamson reactions using a ditriflate derived from diglycerol. All these methodologies permitted further scaling up.
