1382469-17-1Relevant articles and documents
Role of amphiphilicity in the design of synthetic mimics of antimicrobial peptides with gram-negative activity
Thaker, Hitesh D.,Cankaya, Alper,Scott, Richard W.,Tew, Gregory N.
, p. 481 - 485 (2013)
Two new series of aryl SMAMPs (synthetic mimics of antimicrobial peptides) with facially amphiphilic (FA) and disrupted amphiphilic (DA) topologies were designed and synthesized to directly assess the role of amphiphilicity on their antimicrobial activity
POLYCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
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, (2014/07/07)
The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, malaria, mucositis, an ophthalmic infection, an otic infection, a cancer, or a Mycobacterium infection; killing or inhibiting the growth of a Plasmodium species; inhibiting the growth of a Mycobacterium species; modulating an immune response in a mammal; or antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative.
CYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
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, (2013/07/05)
The present invention provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, mucositis, an ophthalmic infection, an otic infection, a cancer, or a Mycobacterium infection; inhibiting the growth of a Mycobacterium species; modulating an immune response in a mammal; or antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative.
Synthetic mimics of antimicrobial peptides with immunomodulatory responses
Thaker, Hitesh D.,Som, Abhigyan,Ayaz, Furkan,Lui, Dahui,Pan, Wenxi,Scott, Richard W.,Anguita, Juan,Tew, Gregory N.
, p. 11088 - 11091 (2012/08/28)
A new series of aryl-based synthetic mimics of antimicrobial peptides (SMAMPs) with antimicrobial activity and selectivity have been developed via systematic tuning of the aromatic groups and charge. The addition of a pendant aromatic group improved the a