138247-61-7Relevant academic research and scientific papers
Synthesis and antiviral activity of methyl derivatives of 9-[2- (phosphonomethoxy)ethyl]guanine
Yu,Bronson,Yang,Patick,Alam,Brankovan,Datema,Hitchcock,Martin
, p. 2958 - 2969 (1992)
A number of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine (PMEG, 1) have been synthesized and tested in vitro for anti-herpes and anti- human immunodeficiency virus (HIV) activity. Among these analogues, (R)-2'- methyl-PMEG [(R)-3] and 2',2'-
Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
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, (2008/06/13)
The present invention provides chiral nucleotide analogs having the Formulas I and II STR1 and pharmaceutically acceptable salts and solvates thereof, and their pharmaceutical compositions for use in the treatment of viral infections, especially those cau
