Synthesis and antiviral activity of methyl derivatives of 9-[2- (phosphonomethoxy)ethyl]guanine

DOI: 10.1021/jm00094a005

Source and publish data:

Journal of Medicinal Chemistry p. 2958 - 2969 (1992)

Update date:2022-08-05

Topics:

Authors:

Bronson Bronson

Yang Yang

Patick Patick

Alam Alam

Brankovan

Datema Datema

Hitchcock

Martin Martin

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Article abstract of DOI:10.1021/jm00094a005

A number of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine (PMEG, 1) have been synthesized and tested in vitro for anti-herpes and anti- human immunodeficiency virus (HIV) activity. Among these analogues, (R)-2'- methyl-PMEG [(R)-3] and 2',2'-

Full text of DOI:10.1021/jm00094a005

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