Synthesis and antiviral activity of methyl derivatives of 9-[2- (phosphonomethoxy)ethyl]guanine

DOI: 10.1021/jm00094a005

Source and publish data:

Journal of Medicinal Chemistry p. 2958 - 2969 (1992)

Update date:2022-08-05

Topics:

Authors:

Bronson Bronson

Yang Yang

Patick Patick

Alam Alam

Brankovan

Datema Datema

Hitchcock

Martin Martin

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00094a005

A number of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine (PMEG, 1) have been synthesized and tested in vitro for anti-herpes and anti- human immunodeficiency virus (HIV) activity. Among these analogues, (R)-2'- methyl-PMEG [(R)-3] and 2',2'-

Full text of DOI:10.1021/jm00094a005

Products guided by the article

Product name:Phosphonic acid, [[1-(iodomethyl)-2-(phenylmethoxy)ethoxy]methyl]-, bis(1-methylethyl) ester, (R)-

Cas No:138247-61-7

R&D Labs maybe for 138247-61-7

Huangshi Meifeng Chemical Co.,ltd.

Contact:+86-714-6516706

Address:1941-4-3#,Hubin Avenue,Huangshi,Hubei,China
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Contact:+86-21-5161 3915

Address:Shanghai YangPu
miao tie sheng

Contact:0311-13263231263

Address:jian hua street,Shijiazhuang City, China
ZHEJIANG JIANYE CHEMICAL CO.,LTD.

Contact:86-571-64149273,64149234

Address:No. 48, Fuxi Road, Meicheng Town
Hunan Shineway Enterprise Co., Ltd.

Contact:+86-731-86303875

Address:118, Huanghua International Airport Road, Huanghua Town, Changsha, Hunan 410137, China

Relevant to this article

Recoverable fluorescence chemosensors for Ni²⁺ ions based on hydrogen-bonded side-chain copolymers presenting pendent benzoic acid and pyridyl receptor units

Doi:10.1039/c2jm31367g
(2012)
Synthesis, characterization and biological evaluation of a novel series of 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazines containing an amide linkage

Doi:10.1002/jhet.1766
(2014)
Engineering metal-organic frameworks immobilize gold catalysts for highly efficient one-pot synthesis of propargylamines

Doi:10.1039/c2gc35284b
(2012)
Cobalt-Catalyzed C?H Functionalizations by Imidate Assistance with Aryl and Alkyl Chlorides

Doi:10.1002/adsc.201600384
(2016)
Free radical mediated ring expansion of vinyl epoxides

Doi:10.1016/0040-4039(91)80225-U
(1991)
A facile access to 3,5-disubstituted oxazolones featuring a Cu-catalyzed cyclization of N-alkynyl tert-butyl carbamates

Doi:10.1246/cl.2012.636
(2012)

Article Doi