1382482-10-1

Basic information

• Product Name: N-{3-[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-pyridin-3-yl-acetamide
• Synonyms: N-{3-[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-pyridin-3-yl-acetamide
• CAS NO: 1382482-10-1
• Molecular Weight: 400.524
• Mol File: 1382482-10-1.mol

Chemical Properties

• CAS DataBase Reference: N-{3-[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-pyridin-3-yl-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{3-[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-pyridin-3-yl-acetamide(1382482-10-1)
• EPA Substance Registry System: N-{3-[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-pyridin-3-yl-acetamide(1382482-10-1)

Safety Data

• Hazardous Substances Data: 1382482-10-1(Hazardous Substances Data)

Upstream product

• 1369303-80-9 1-[2-(3-nitrophenyl)ethyl]-4-phenylpiperazine 
• 1369303-78-5 2-(3-nitrophenyl)-1-(4-phenylpiperazin-1-yl)ethanone 
• 501-81-5 pyridyl-3-yl-acetic acid 
• 1018265-20-7 3-[2-(4-phenylpiperazin-1-yl)ethyl]phenylamine 

Relevant articles and documents

Interactions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl- acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D2 and 5-hydroxytryptamine 5HT1A receptors

It is suggested that the ratio of dopamine D2 to 5-hydroxytryptamine 5-HT1A activity is an important parameter that determines the efficiency of antipsychotic drugs. Here we present the synthesis of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas and their structure-activity relationship studies on dopamine D2 and 5-hydrohytryptamine 5-HT1A receptors. It was shown that ligand selectivity and affinity strongly depends on their topology and the presence of a pyridyl group in the head of molecules. Molecular modeling studies using homology modeling and docking simulation revealed a rational explanation for the ligand behavior. The observed binding modes and receptor-ligand interactions provided us with a clue for optimizing the optimal selectivity towards 5-HT 1A receptors.