138249-74-8

Basic information

• Product Name: Cyclohexanone, 2-(2,2,2-trifluoro-1-hydroxyethyl)-
• CAS NO: 138249-74-8
• Molecular Formula: C8H11F3O2
• Molecular Weight: 196.169
• Mol File: 138249-74-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Cyclohexanone, 2-(2,2,2-trifluoro-1-hydroxyethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanone, 2-(2,2,2-trifluoro-1-hydroxyethyl)-(138249-74-8)
• EPA Substance Registry System: Cyclohexanone, 2-(2,2,2-trifluoro-1-hydroxyethyl)-(138249-74-8)

Safety Data

• Hazardous Substances Data: 138249-74-8(Hazardous Substances Data)

Upstream product

• 75-90-1 2,2,2-Trifluoroacetaldehyde 
• 108-94-1 cyclohexanone 
• 433-27-2 ethyl trifluoroacetaldehyde hemiacetal 
• 188429-64-3 2,2,2-trifluoro-N,N,N',N'-tetramethylethane-1,1-diamine 
• 6651-36-1 1-(Trimethylsilyloxy)cyclohexene 

Relevant articles and documents

Organocatalytic asymmetric direct aldol reactions of trifluoroacetaldehyde ethyl hemiacetal with aromatic methyl ketones

The organocatalytic asymmetric direct aldol reaction of trifluoroacetaldehyde ethyl hemiacetal with aromatic methyl ketones in the presence of a catalytic amount of (S)-5-(pyrrolidin-2-yl)-1H-tetrazole in dichloroethane at 40 °C proceeds smoothly to produ

Facile Synthesis of α-Trifluoromethylated Alcohols from Trifluoroacetaldehyde Ethyl Hemiacetal

Trifluoroacetaldehyde ethyl hemiacetal reacted with nucleophilic organosilanes such as cyanotrimethylsilane, allyltrimethylsilane, or enol trimethylsilyl ethers in the presence of Lewis acid to afford a series of α-trifluoromethylated alcohols in high yield. Key Words: trifluoroacetaldehyde ethyl hemiacetal; Lewis acid; trimethylsilylated nucleophiles; carbon-carbon bond formation; α-trifluoromethylated alcohol.