138249-74-8Relevant academic research and scientific papers
Organocatalytic asymmetric direct aldol reactions of trifluoroacetaldehyde ethyl hemiacetal with aromatic methyl ketones
Funabiki, Kazumasa,Itoh, Yuya,Kubota, Yasuhiro,Matsui, Masaki
experimental part, p. 3545 - 3550 (2011/06/22)
The organocatalytic asymmetric direct aldol reaction of trifluoroacetaldehyde ethyl hemiacetal with aromatic methyl ketones in the presence of a catalytic amount of (S)-5-(pyrrolidin-2-yl)-1H-tetrazole in dichloroethane at 40 °C proceeds smoothly to produ
Facile synthesis of trifluoromethyl carbinols and trifluoromethyl- α,β-unsaturated ketones from the new CF3CHO synthetic equivalent, 1,1- bis(dimethylamino)-2,2,2-trifluoroethane
Xu, Yuelian,Dolbier Jr., William R.
, p. 9151 - 9154 (2007/10/03)
1,1-Bis(dimethylamino)-2,2,2-trifluoroethane is an excellent synthetic building-block replacement for trifluoroacetaldehyde in condensation reactions with ketones using 36% aqueous HCl catalysis. Moderate to good yields (43-68%) of trifluoromethyl carbino
Facile Synthesis of α-Trifluoromethylated Alcohols from Trifluoroacetaldehyde Ethyl Hemiacetal
Kubota, Toshio,Iijima, Masahiro,Tanaka, Tatsuo
, p. 1351 - 1354 (2007/10/02)
Trifluoroacetaldehyde ethyl hemiacetal reacted with nucleophilic organosilanes such as cyanotrimethylsilane, allyltrimethylsilane, or enol trimethylsilyl ethers in the presence of Lewis acid to afford a series of α-trifluoromethylated alcohols in high yield. Key Words: trifluoroacetaldehyde ethyl hemiacetal; Lewis acid; trimethylsilylated nucleophiles; carbon-carbon bond formation; α-trifluoromethylated alcohol.
