138271-16-6

Basic information

• Product Name: (Z)-(2,4-difluorophenyl) (4-piperidinyl)methanone, oxime monohydrochloride
• Synonyms: (Z)-(2,4-difluorophenyl) (4-piperidinyl)methanone, oxime monohydrochloride
• CAS NO: 138271-16-6
• Molecular Weight: 276.714
• Mol File: 138271-16-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-(2,4-difluorophenyl) (4-piperidinyl)methanone, oxime monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-(2,4-difluorophenyl) (4-piperidinyl)methanone, oxime monohydrochloride(138271-16-6)
• EPA Substance Registry System: (Z)-(2,4-difluorophenyl) (4-piperidinyl)methanone, oxime monohydrochloride(138271-16-6)

Safety Data

• Hazardous Substances Data: 138271-16-6(Hazardous Substances Data)

Usage

General Description

(Z)-(2,4-difluorophenyl) (4-piperidinyl)methanone, oxime monohydrochloride is a chemical compound that belongs to the class of oxime derivatives. It is often used in research and experimental settings as a reagent or intermediate in the synthesis of various compounds. This particular compound is notable for its use in the development of pharmaceuticals and agrochemicals. It has the potential to exhibit biological activity, such as serving as a ligand for certain receptors or enzymes. The monohydrochloride salt form of this compound is commonly used for its increased solubility and stability in various experimental conditions. Overall, (Z)-(2,4-difluorophenyl) (4-piperidinyl)methanone, oxime monohydrochloride is a versatile chemical with potential applications in the fields of medicinal chemistry, pharmacology, and organic synthesis.

Downstream Products

• 144598-75-4 paliperidone 
• 1388021-46-2 C₂₃H₂₈F₂N₄O₃ 

Relevant articles and documents

Preparation method of palipefidone

The invention provides a preparation method of palipefidone. The preparation method comprises the following steps: dissolving a palipefidone crude product into a heated alcohol solution; adding active carbon under a heating condition; keeping heat and stirring; filtering when the solution is hot to obtain a filtrate; at a temperature of 45 DEG C to 60 DEG C, adding a reducing agent into the filtrate, and keeping the heat and stirring for 30 to 60 minutes; after stirring, controlling to cool for 8 DEG C to 15 DEG C every hour; slowly cooling and crystallizing; after crystallizing, filtering to obtain a solid and a refined mother solution respectively; performing water washing, alcohol washing and vacuum drying on the obtained solid to obtain palipefidone crystallized powder; decompressing and concentrating the refined mother solution and recycling palipefidone secondary precipitate. The preparation method of the palipefidone is simple in process and convenient to operate, does not need special equipment and is suitable for industrial production; a toxin-free or low-toxin solvent is adopted, so that environmental pollution is lowered; the prepared product has high purity, and the content of 9-keto impurities is reduced to be 0.05 percent, even lower.