1388021-46-2

Basic information

• Product Name: C₂₃H₂₈F₂N₄O₃
• CAS NO: 1388021-46-2
• Molecular Weight: 446.497
• Mol File: 1388021-46-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₈F₂N₄O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₈F₂N₄O₃(1388021-46-2)
• EPA Substance Registry System: C₂₃H₂₈F₂N₄O₃(1388021-46-2)

Safety Data

• Hazardous Substances Data: 1388021-46-2(Hazardous Substances Data)

Usage

Uses

Paliperidone E-oxime is an impurity of Paliperidone (P141000), a known orally active antipsychotic agent.

Upstream product

• 130049-82-0 3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one 
• 138271-16-6 (Z)-(2,4-difluorophenyl) (4-piperidinyl)methanone, oxime monohydrochloride 
• 135634-18-3 (2,4-difluorophenyl)-piperidin-4-yl-methanone oxime hydrochloride 
• 1141761-79-6 C₃₀H₃₀F₂N₄O₃ 

Relevant articles and documents

Preparation method of palipefidone

The invention provides a preparation method of palipefidone. The preparation method comprises the following steps: dissolving a palipefidone crude product into a heated alcohol solution; adding active carbon under a heating condition; keeping heat and stirring; filtering when the solution is hot to obtain a filtrate; at a temperature of 45 DEG C to 60 DEG C, adding a reducing agent into the filtrate, and keeping the heat and stirring for 30 to 60 minutes; after stirring, controlling to cool for 8 DEG C to 15 DEG C every hour; slowly cooling and crystallizing; after crystallizing, filtering to obtain a solid and a refined mother solution respectively; performing water washing, alcohol washing and vacuum drying on the obtained solid to obtain palipefidone crystallized powder; decompressing and concentrating the refined mother solution and recycling palipefidone secondary precipitate. The preparation method of the palipefidone is simple in process and convenient to operate, does not need special equipment and is suitable for industrial production; a toxin-free or low-toxin solvent is adopted, so that environmental pollution is lowered; the prepared product has high purity, and the content of 9-keto impurities is reduced to be 0.05 percent, even lower.

Processes for the Preparation of Paliperidone and Pharmaceutically Acceptable Salts Thereof and Intermediates for Use in the Processes

The present invention relates to novel compounds of formula (VIII) and (X), processes for their preparation and their use in the preparation of paliperidone or a salt thereof. There is also provided by the present invention novel processes for preparing intermediates for use in the preparation of paliperidone or a salt thereof, and novel processes for preparing paliperidone or a salt thereof.