138285-38-8 Usage
Uses
Used in Pharmaceutical Industry:
(6aR-trans)-1-[(tert-Butyl)diMethylsilyloxy is used as an intermediate compound for the synthesis of a major Tetrahydrocannabinol (T293200) metabolite. This application is significant because Tetrahydrocannabinol is a primary psychoactive compound found in cannabis plants, and its metabolites have potential therapeutic applications in various medical conditions, such as pain relief, appetite stimulation, and anti-inflammatory effects.
In the synthesis process, (6aR-trans)-1-[(tert-Butyl)diMethylsilyloxy plays a crucial role in the formation of the desired metabolite, enabling the development of new pharmaceutical products and potential treatments for various health issues. Its unique reactivity and properties make it a valuable component in the design and synthesis of complex organic molecules, particularly in the context of drug development and pharmaceutical research.
Check Digit Verification of cas no
The CAS Registry Mumber 138285-38-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,8,2,8 and 5 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 138285-38:
(8*1)+(7*3)+(6*8)+(5*2)+(4*8)+(3*5)+(2*3)+(1*8)=148
148 % 10 = 8
So 138285-38-8 is a valid CAS Registry Number.
138285-38-8Relevant academic research and scientific papers
Studies on the synthesis of (-)-11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THC) and related compounds: An improved oxidative procedure
Siegel,Gordon,Razdan
, p. 851 - 853 (2007/10/02)
A facile procedure is described whereby Δ9-THC aldehydes 4, as their tert-butyldimethylsilyl derivatives, are conveniently oxidized to the corresponding acids with sodium chlorite in the presence of a large excess of 2-methyl-2-butene without isomerization of the Δ9-double bond. Deprotection of the O-protecting group with tetrabutylammonium fluoride in tetrahydrofuran gave the acids 2 in an overall yield of ≥80%. A study of other oxidizing agents and protecting groups demonstrated that this is the procedure of choice for the preparation of 9-carboxy-Δ9-tetrahydrocannabinols.
