1382900-07-3

Upstream product

• 1225196-52-0 5-(4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 1382900-46-0 3-(4-isopropyl thiazol-2-yl)-4-phenyl-5-((5-phenyl-1,3,4-oxadiazol-2-yl) methylthio)-4H-1,2,4-triazole 
• 1382900-49-3 3-((5-(chloromethyl)-1,3,4-oxadiazol-2-yl)methylthio)-5-(4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazole 
• 1382900-55-1 3-(4-isopropylthiazol-2-yl)-5-((5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl)methylthio)-4-phenyl-4H-1,2,4-triazole 
• 1382900-58-4 3-(4-isopropylthiazol-2-yl)-4-phenyl-5-((5-p-tolyl-1,3,4-oxadiazol-2-yl)methylthio)-4H-1,2,4-triazole 
• 1382900-61-9 4-(5-((5-(4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazol-3-ylthio)methyl)-1,3,4-oxadiazol-2-yl)phenol 
• 1382900-10-8 (((4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetohydrazide 
• 1382900-13-1 N'-(3,4-dimethoxybenzylidene)-((4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazol-3-ylthio)acetohydrazide 
• 1382900-16-4 N'-(4-chlorobenzylidene)-((4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazol-3-ylthio)acetohydrazide 
• 1382900-19-7 N'-(4-hydroxybenzylidene)-((4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazol-3-ylthio)acetohydrazide??????????????????????? 
• 1382900-25-5 N'-(3-nitrobenzylidene)-((4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazol-3-ylthio)acetohydrazide?????????????????? 

Relevant academic research and scientific papers

Synthesis and pharmacological evaluation of novel 4-isopropylthiazole-4- phenyl-1,2,4-triazole derivatives as potential antimicrobial and antitubercular agents

A series of novel 4-isopropylthiazol-4-phenyl-1,2,4-triazol derivatives, N′-(substituted benzylidene)-2-(5-(4-isopropylthiazol-2-yl)-4-phenyl-4H-1, 2,4-triazol-3-ylthio)acetohydrazides 4a-e, 4-isopropylthiazol-2-yl-4′- phenyl-4′H-1′, 2′,4′-triazol-3′-ylthio (substituted methyl benzylidene) acetohydrazides 5a-f, 3-(4-isopropylthiazol-2- yl)-4-phenyl-5-(5-substituted-1,3,4-oxadiazol-2-ylthio)-4H-1,2,4-triazole derivatives 6a-f and N-acetyl-5′-(4-isopropylthiazol-2-yl)-4′- phenyl-4′H-1,2,4-triazol-3′-ylthio) acetohydrazide 7 were synthesized and characterized by spectroscopy, elemental, and mass spectral analysis. These compounds were evaluated for their preliminary in vitro antibacterial, antifungal, and antitubercular activity against Mycobacterium tuberculosis (M. tuberculosis) H37Rv strain by broth dilution assay method. All the compounds exhibited moderate to significant antibacterial and antifungal activities. Results of the antitubercular screening against Mycobacterium tuberculosis H37Rv showed that compounds 4c and 6c exhibited good antitubercular activity when compared with first line drug isoniazid.