1382922-85-1

Basic information

• Product Name: 2-[3-(4-bromophenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-5-(2-methoxybenzylidene)-1,3-thiazol-4(5H)-one
• CAS NO: 1382922-85-1
• Molecular Weight: 552.879
• Mol File: 1382922-85-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[3-(4-bromophenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-5-(2-methoxybenzylidene)-1,3-thiazol-4(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[3-(4-bromophenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-5-(2-methoxybenzylidene)-1,3-thiazol-4(5H)-one(1382922-85-1)
• EPA Substance Registry System: 2-[3-(4-bromophenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-5-(2-methoxybenzylidene)-1,3-thiazol-4(5H)-one(1382922-85-1)

Safety Data

• Hazardous Substances Data: 1382922-85-1(Hazardous Substances Data)

Upstream product

• 1279691-23-4 3-(4-bromophenyl)-5-(4-chlorophenyl)-4,5-dihydropyrazole-1-carbothioamide 
• 79-11-8 chloroacetic acid 
• 135-02-4 ortho-anisaldehyde 
• 296271-45-9 1-(4-bromophenyl)-3-(4-chlorophenyl)propan-1-one 

Relevant articles and documents

Synthesis, characterization, and biological evaluation of certain 1,3-thiazolone derivatives bearing pyrazoline moiety as potential anti-breast cancer agents

A series of 5-arylidene-2-(3,5-diaryl-4,5-dihydro-1H-pyrazol-1-yl)-1,3- thiazol-4(5H)-ones were synthesized and screened for their in vitro antitumor activity against human breast adenocarcinoma cell line (MCF-7). Five of the test compounds exhibited good antitumor activity superior to the reference drug, doxorubicin, with IC50 range 1.4-2.3 μM. Among the test compounds, 2-[3,5-bis(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-5-(2- methoxybenzylidene)-1,3-thiazol-4(5H)-one (3i) was found to show the most potent anticancer activity.